NPM1

Gene Symbol	NPM1
Entrez Gene	4869
Alt Symbol	B23, NPM
Species	Human
Gene Type	protein-coding
Description	nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Other Description	nucleolar protein NO38|nucleophosmin|nucleophosmin/nucleoplasmin family, member 1
Swissprots	A8K3N7 P06748 Q96EA5 Q8WTW5 B5BU00 Q5EU97 Q5EU98 Q5EU96 Q5EU99 P08693 Q12826 Q9UDJ7 Q96AT6 Q13440 Q5EU95 Q9BYG9 Q5EU94 Q14115 Q96DC4 D3DQL6 Q13441 Q6V962
Accessions	AAB94739 ACA50454 EAW61443 EAW61444 EAW61445 EAW61446 EAW61447 EAW61448 EAW61449 P06748 AB042278 BAB40600 AB451236 BAG70050 AB451361 BAG70175 AI687394 AK000472 BAA91188 AK290652 BAF83341 AY347529 AAQ24860 AY740634 AAW67752 AY740635 AAW67753 AY740636 AAW67754 AY740637 AAW67755 AY740638 AAW67756 AY740639 AAW67757 AY740640 AAW67758 BC002398 AAH02398 BC003670 AAH03670 BC008495 AAH08495 BC009623 AAH09623 BC012566 AAH12566 BC014349 AAH14349 BC016716 AAH16716 BC016768 AAH16768 BC016824 AAH16824 BC020467 BC021668 AAH21668 BC021983 AAH21983 BC024716 BC050628 AAH50628 BC107754 AAI07755 BP291033 BT007011 AAP35657 BU661768 D28343 BAA05709 DQ303464 ABC40399 DQ892032 ABM82958 DQ895223 ABM86149 EF429251 ABP97432 J02590 AAA36473 M23613 AAA36380 M26697 AAA36385 M28699 AAA58386 M31004 AAA36474 X16934 CAA34809 XM_005265920 XP_005265977 XM_011534564 XP_011532866 NM_001037738 NP_001032827 NM_002520 NP_002511 NM_199185 NP_954654
Function	Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double- stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylati
Subcellular Location	Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Can shuttle between cytoplasm and nucleus. Co- localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

B23 CRISPR/Cas9 KO Plasmid (h) - sc-416302 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

B23 HDR Plasmid (h) - sc-416302-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

B23 Double Nickase Plasmid (h) - sc-416302-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

B23 Double Nickase Plasmid (h2) - sc-416302-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

B23 CRISPR Activation Plasmid (h) - sc-416302-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

B23 CRISPR Activation Plasmid (h2) - sc-416302-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

B23 Lentiviral Activation Particles (h) - sc-416302-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

B23 Lentiviral Activation Particles (h2) - sc-416302-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

B23 siRNA (h) - sc-29771 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

B23 shRNA Plasmid (h) - sc-29771-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

B23 shRNA (h) Lentiviral Particles - sc-29771-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NPM1 RNAi - H00004869-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

NPM1 RNAi - H00004869-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU115611 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15460 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15460 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02677 from Sigma-Aldrich Category miRNA

NPM1 siRNA (Human) - CRH3238 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human NPM1 (NM_199185.3) - SHH354312 from Creative biogene Category siRNA Species Reactivities Human

NPM1 shRNA Plasmid (Human) - CHH3238 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

NPM1 miRNA 3'UTR clone - MiUTR3H-01576 from Creative biogene Species Reactivities Human

NPM1 miRNA 3'UTR clone - MiUTR3H-01577 from Creative biogene Species Reactivities Human

NPM1 miRNA 3'UTR clone - MiUTR3H-01578 from Creative biogene Species Reactivities Human

Search more