| Gene Symbol |
ENO1
|
| Entrez Gene |
2023
|
| Alt Symbol |
ENO1L1, MPB1, NNE, PPH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
enolase 1, (alpha)
|
| Other Description |
2-phospho-D-glycerate hydro-lyase|MYC promoter-binding protein 1|alpha enolase like 1|alpha-enolase|enolase-alpha|non-neural enolase|phosphopyruvate hydratase|plasminogen-binding protein|tau-crystallin
|
| Swissprots |
Q53FT9 B2RD59 Q96GV1 Q7Z3V6 Q71V37 Q8WU71 Q16704 Q4TUS4 Q9UM55 Q9UCH6 Q9BT62 Q658M5 P22712 Q6GMP2 P06733 Q53HR3
|
| Accessions |
AAY43128 CAA34360 CBN61326 EAW71604 EAW71605 P06733 AF035286 AAB88178 AK098420 AK222517 BAD96237 AK223192 BAD96912 AK298600 BAH12823 AK309177 AK309291 AK315417 BAG37806 AL833741 CAH56247 AM393606 CAL38482 BC001810 AAH01810 BC004325 AAH04325 BC004458 AAH04458 BC009218 AAH09218 BC009912 AAH09912 BC011130 AAH11130 BC015641 AAH15641 BC021166 AAH21166 BC022545 AAH22545 BC027725 AAH27725 BC050642 AAH50642 BC113034 AAI13035 BT007163 AAP35827 BX537400 CAD97642 D28437 BAA05803 DQ891441 ABM82367 DQ894619 ABM85545 EF036495 ABO65081 GU170215 ADK47995 M14328 AAA52387 M55914 AAA35698 X84907 CAA59331 XM_006710433 XP_006710496 NM_001201483 NP_001188412 NM_001428 NP_001419
|
| Function |
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10802057}. Cell membrane {ECO:0000269|PubMed:10802057}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:10802057}. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line.
|
| Tissue Specificity |
The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
|
| Top Pathways |
Glycolysis / Gluconeogenesis, RNA degradation, Biosynthesis of amino acids, Carbon metabolism
|
