| Gene Symbol | Chst12 |
|---|---|
| Entrez Gene | 59031 |
| Alt Symbol | AI595374, C4S-2, C4ST2 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | carbohydrate sulfotransferase 12 |
| Other Description | chondroitin 4-O-sulfotransferase 2|chondroitin 4-sulfotransferase 2 |
| Swissprots | Q9JJS3 Q99LL3 Q3TCX9 |
| Accessions | EDL19118 Q99LL3 AJ289132 CAB92140 AK142155 BAE24951 AK163588 BAE37408 AK170209 AK170484 BAE41826 AK171208 BAE42314 BB868264 BC003201 AAH03201 XM_006504725 XP_006504788 NM_021528 NP_067503 |
| Function | Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor (By similarity). {ECO:0000250}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |