Gene Symbol | Chst12 |
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Entrez Gene | 59031 |
Alt Symbol | AI595374, C4S-2, C4ST2 |
Species | Mouse |
Gene Type | protein-coding |
Description | carbohydrate sulfotransferase 12 |
Other Description | chondroitin 4-O-sulfotransferase 2|chondroitin 4-sulfotransferase 2 |
Swissprots | Q9JJS3 Q99LL3 Q3TCX9 |
Accessions | EDL19118 Q99LL3 AJ289132 CAB92140 AK142155 BAE24951 AK163588 BAE37408 AK170209 AK170484 BAE41826 AK171208 BAE42314 BB868264 BC003201 AAH03201 XM_006504725 XP_006504788 NM_021528 NP_067503 |
Function | Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor (By similarity). {ECO:0000250}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
C4ST-2 CRISPR/Cas9 KO Plasmid (m) - sc-425573 from Santa Cruz Biotechnology
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C4ST-2 HDR Plasmid (m) - sc-425573-HDR from Santa Cruz Biotechnology
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C4ST-2 Double Nickase Plasmid (m) - sc-425573-NIC from Santa Cruz Biotechnology
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C4ST-2 Double Nickase Plasmid (m2) - sc-425573-NIC-2 from Santa Cruz Biotechnology
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C4ST-2 CRISPR Activation Plasmid (m) - sc-425573-ACT from Santa Cruz Biotechnology
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C4ST-2 CRISPR Activation Plasmid (m2) - sc-425573-ACT-2 from Santa Cruz Biotechnology
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C4ST-2 Lentiviral Activation Particles (m) - sc-425573-LAC from Santa Cruz Biotechnology
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C4ST-2 Lentiviral Activation Particles (m2) - sc-425573-LAC-2 from Santa Cruz Biotechnology
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C4ST-2 siRNA (m) - sc-62113 from Santa Cruz Biotechnology
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C4ST-2 shRNA Plasmid (m) - sc-62113-SH from Santa Cruz Biotechnology
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C4ST-2 shRNA (m) Lentiviral Particles - sc-62113-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU017921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN28743 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28743 from Sigma-Aldrich
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CHST12 siRNA (Mouse) - CRM6183 from Cohesion Biosciences
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CHST12 - MBS8219414 from MyBioSource
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shRNA set against Mouse CHST12 (NM_021528.3) - SHH263745 from Creative biogene
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Mouse CHST12 siRNA - orb285659 from Biorbyt
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CHST12 shRNA Plasmid (Mouse) - CHM6183 from Cohesion Biosciences
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CHST12 miRNA 3'UTR clone - MiUTR1M-03031 from Creative biogene
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