| Gene Symbol |
TFAP2D
|
| Entrez Gene |
83741
|
| Alt Symbol |
TFAP2BL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
|
| Other Description |
AP-2 like|AP2-delta|activating enhancer binding protein 2 beta-like 1|activating enhancer-binding protein 2-delta|transcription factor AP-2 beta (activating enhancer binding protein 2 beta)-like 1|transcription factor AP-2 beta (activating enhancer-binding protein 2 beta)-like 1|transcription factor AP-2-beta-like 1|transcription factor AP-2-delta
|
| Swissprots |
Q7Z6R9 Q8IWX0
|
| Accessions |
EAX04354 Q7Z6R9 AY028376 AAK16926 BC144200 BC166653 AAI66653 DT221015 NM_172238 NP_758438
|
| Function |
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in brain, placenta, skeletal muscle, thymus, small intestine, and prostate, and expressed at lower levels in leukocyte, spleen, testis, ovary and colon. Barely detectable in heart, kidney, liver, lung or pancreas. {ECO:0000269|PubMed:11733187}.
|
![Western Blot: TFAP2D Overexpression Lysate (Adult Normal) [NBP2-05173] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TFAP2D.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5316_TFAP2D%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05173-img0001.jpg)