Gene Symbol | QSOX1 |
---|---|
Entrez Gene | 5768 |
Alt Symbol | Q6, QSCN6 |
Species | Human |
Gene Type | protein-coding |
Description | quiescin Q6 sulfhydryl oxidase 1 |
Other Description | hQSOX|sulfhydryl oxidase 1 |
Swissprots | Q8WVP4 Q59G29 Q8TDL6 Q5T2X0 O00391 |
Accessions | EAW91076 EAW91077 O00391 AB209280 BAD92517 AF361868 AAM00263 AK092177 AK290842 BAF83531 AK290887 BAF83576 AY358941 AAQ89300 BC017692 AAH17692 BC100023 AAI00024 BX382719 CB137990 DQ584886 JF432792 ADZ16009 L42379 AAA89173 U97276 AAC09010 NM_001004128 NP_001004128 NM_002826 NP_002817 |
Function | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor- suppressing capabilities being involved in growth regulation. {ECO:0000269|PubMed:10542195, ECO:0000269|PubMed:10708601, ECO:0000269|PubMed:12176051, ECO:0000269|PubMed:16806532, ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:18393449}. |
Subcellular Location | Isoform 1: Golgi apparatus membrane; Single- pass membrane protein. |
Tissue Specificity | Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney. {ECO:0000269|PubMed:10708601, ECO:0000269|Ref.9}. |