| Gene Symbol |
Selp
|
| Entrez Gene |
25651
|
| Alt Symbol |
PSELECT
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
selectin P
|
| Other Description |
CD62 antigen-like family member P|GMP-140|LECAM3|P-selectin|PADGEM|granule membrane protein 140|leukocyte-endothelial cell adhesion molecule 3|platelet activation dependent granule-external membrane protein|selectin, platelet
|
| Swissprots |
P98106
|
| Accessions |
EDM09362 P98106 BC101919 AAI01920 L23088 AAA60325 XM_006250150 XP_006250212 NM_013114 NP_037246
|
| Function |
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in all tissues examined: spleen, lung, brain, liver, heart, kidney, thymus and small intestine.
|
| Top Pathways |
Cell adhesion molecules (CAMs), Staphylococcus aureus infection, Malaria
|