Gene Symbol | BCL2A1 |
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Entrez Gene | 597 |
Alt Symbol | ACC-1, ACC-2, ACC1, ACC2, BCL2L5, BFL1, GRS, HBPA1 |
Species | Human |
Gene Type | protein-coding |
Description | BCL2-related protein A1 |
Other Description | bcl-2-like protein 5|bcl-2-related protein A1|bcl2-L-5|hematopoietic BCL2-related protein A1|hemopoietic-specific early response protein|protein BFL-1 |
Swissprots | Q86W13 Q16548 Q6FGZ4 Q99524 Q6FH19 |
Accessions | CBX47512 EAW99129 Q16548 AL110097 AY234180 AAO89009 BC016281 AAH16281 BG198875 BG204033 BG216703 BT007103 AAP35767 CD640106 CR541937 CAG46735 CR541962 CAG46760 DQ891109 ABM82035 DQ894290 ABM85216 U27467 AAC50288 U29680 AAC50438 Y09397 CAA70566 NM_001114735 NP_001108207 NM_004049 NP_004040 |
Function | Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies. |
Top Pathways | Transcriptional misregulation in cancer |
A1 CRISPR/Cas9 KO Plasmid (h) - sc-416421 from Santa Cruz Biotechnology
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A1 HDR Plasmid (h) - sc-416421-HDR from Santa Cruz Biotechnology
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A1 Double Nickase Plasmid (h) - sc-416421-NIC from Santa Cruz Biotechnology
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A1 Double Nickase Plasmid (h2) - sc-416421-NIC-2 from Santa Cruz Biotechnology
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A1 CRISPR Activation Plasmid (h) - sc-416421-ACT from Santa Cruz Biotechnology
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A1 CRISPR Activation Plasmid (h2) - sc-416421-ACT-2 from Santa Cruz Biotechnology
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A1 Lentiviral Activation Particles (h) - sc-416421-LAC from Santa Cruz Biotechnology
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A1 Lentiviral Activation Particles (h2) - sc-416421-LAC-2 from Santa Cruz Biotechnology
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A1 siRNA (h) - sc-37285 from Santa Cruz Biotechnology
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A1 shRNA Plasmid (h) - sc-37285-SH from Santa Cruz Biotechnology
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A1 shRNA (h) Lentiviral Particles - sc-37285-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU100801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3907 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3907 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00021 from Sigma-Aldrich
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BCL2A1 siRNA (Human) - CRH0410 from Cohesion Biosciences
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Bcl-2 related protein A1 RNAi - H00000597-R01 from Novus Biologicals
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BCL2A1 - MBS8240635 from MyBioSource
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shRNA set against Human BCL2A1 (NM_004049.3) - SHH245894 from Creative biogene
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shRNA set against Human BCL2A1(NM_004049.3) - SHG096911 from Creative biogene
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BCL2A1 shRNA Plasmid (Human) - CHH0410 from Cohesion Biosciences
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BCL2A1 miRNA 3'UTR clone - MiUTR1H-00841 from Creative biogene
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BCL2A1 miRNA 3'UTR clone - MiUTR3H-03845 from Creative biogene
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