| Gene Symbol |
ANLN
|
| Entrez Gene |
54443
|
| Alt Symbol |
FSGS8, Scraps, scra
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
anillin, actin binding protein
|
| Other Description |
actin-binding protein anillin
|
| Swissprots |
Q9H8Y4 Q6NSK5 Q9NVP0 Q5CZ78 Q9NVN9 Q9NQW6
|
| Accessions |
CAL40337 EAW94067 EAW94068 EAW94069 EAW94070 EAW94071 EAW94072 Q9NQW6 AF273437 AAF75796 AK001468 BAA91710 AK001472 BAA91711 AK023208 BAB14463 AK094574 AK291254 BAF83943 AK299803 BAG61678 BC034692 AAH34692 BC070066 AAH70066 BE885510 BQ434804 BU630923 CR936650 CAI56788 XM_006715746 XP_006715809 XM_006715747 XP_006715810 NM_001284301 NP_001271230 NM_001284302 NP_001271231 NM_018685 NP_061155
|
| Function |
Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:24676636}.
|
| Subcellular Location |
Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.
|
| Tissue Specificity |
Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors. {ECO:0000269|PubMed:16203764, ECO:0000269|PubMed:24676636}.
|