F8

Gene Symbol F8
Entrez Gene 2157
Alt Symbol AHF, DXS1253E, F8B, F8C, FVIII, HEMA
Species Human
Gene Type protein-coding
Description coagulation factor VIII, procoagulant component
Other Description antihemophilic factor|coagulation factor VIII|coagulation factor VIIIc|factor VIII F8B
Swissprots Q14286 Q5HY69 P00451
Accessions AAA52420 AAB61261 AAC32196 AAD50437 AAV85964 ABB58721 ABC25733 ABC25738 ABC25743 ABC25748 ABC25753 ABC25762 ABC25767 ABC25772 ABC25777 ABC25782 ABC25787 ABC25792 ABC25797 ABC25802 ABC25807 ABC25812 ABC25817 ABC25822 ABC25827 ABC25832 ABC25837 ABC25842 ABC25847 ABC25852 ABC25857 ABC25862 ABC25867 ABC25872 ABC25877 ABC25882 ABC25887 ABC25892 ABC25897 ABC25902 ABC25907 ABC25912 ABC25917 ABC25922 ABC25927 ABC25932 ABC25937 ABC25942 ABC25947 ABC25952 ABC25957 ABC25962 ABC25967 ABC25972 ABC25977 ABC25982 ABI26644 ABJ51912 ABJ51913 ABJ51914 ABJ51915 ABJ51916 ABJ51917 ABJ51918 ABJ51919 ABJ51920 ABJ51921 ABJ51922 ABJ51923 ABJ51924 ABJ51925 ABJ51926 ABJ51927 ABJ51928 ABJ51929 ABJ51930 ABJ55908 ABJ55909 ABJ55910 ABJ55911 ABJ55912 ABJ55913 ABK19827 ABK19828 ABK19829 ABK19830 ABK19831 ABQ51215 ACC77588 ADO65749 ADO65750 ADO65751 ADO65752 ADO65753 ADZ72842 AER23831 BAA94310 BAA94311 BAA94312 CAA25612 CAB40351 CAV28538 EAW72645 EAW72646 EAW72647 P00451 AK289947 BAF82636 AK292902 BAF85591 AK295164 BAH11996 AK307726 AK313707 BAG36452 AX746360 CAD97566 BC022513 AAH22513 BC064380 AAH64380 BC098389 AAH98389 BC111967 AAI11968 BC111969 AAI11970 BC150305 BC166700 AAI66700 BI547023 FN811132 CBL59398 JF916726 AEI17944 K01740 AAA52484 M14113 AAA52485 M90707 AAA58466 X01179 CAA25619 XM_011531126 XP_011529428 NM_000132 NP_000123 NM_019863 NP_063916
Function Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.
Subcellular Location Secreted, extracellular space.
Top Pathways Complement and coagulation cascades

Factor VIII (E-16) - sc-27649 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Factor VIII (E-16): sc-27649. Western blot analysis of Factor VIII expression in rat liver tissue extract.

Factor VIII (F-15) - sc-27650 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Factor VIII (F-15): sc-27650. Immunofluorescence staining of methanol-fixed Caki-1 cells showing cytoplasmic localization.

Factor VIII (H-19) - sc-27647 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Factor VIII (H-19): sc-27647. Western blot analysis of Factor VIII expression in mouse kidney tissue extract.

Factor VIII (D-15) - sc-27651 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Factor VIII heavy chain (H-140) - sc-33583 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Factor VIII heavy chain (H-140): sc-33583. Western blot analysis of Factor VIII heavy chain expression in human platelet extract.

Factor VIII light chain (H-100) - sc-33584 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Factor VIII light chain (H-100): sc-33584. Immunofluorescence staining of normal mouse intestine frozen section showing cytoplasmic and extracellular staining.

Factor VIII light chain (RFFVIII C/5) - sc-59512 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Factor VIII light chain (RFFVIII C/5): sc-59512. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules and staining of plasma in blood vessels.

Factor VIII (R8B12) - sc-73597 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Factor VIII (R8B12): sc-73597. Western blot analysis of Factor VIII expression in human PBL (A) and Hep G2 (B) whole cell lysates and human kidney tissue extract (C).

Factor VIII (012) - sc-59508 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Factor VIII (012): sc-59508. Western blot analysis of Factor VIII expression in Hep G2 (A), K-562 (B) and Jurkat (C) whole cell lysates.

Factor VIII (GMA-8011) - sc-65950 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Factor VIII (GMA-8002) - sc-65949 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Factor VIII (GMA-012) - sc-65947 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Factor VIII (GMA-012): sc-65947. Western blot analysis of Factor VIII expression in Hep G2 (A), K-562 (B) and Jurkat (C) whole cell lysates.

Factor VIII (GMA-8001) - sc-65948 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Factor VIII (102) - sc-59510 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µl ascites
Host Mouse
Clonality Monoclonal
Factor VIII (102): sc-59510. Western blot analysis of Factor VIII expression in K-562 (A) and Jurkat (B) whole cell lysates.

Factor VIII (RFFVIIIC/8) - sc-59514 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-Factor VIII + VIII A2domain antibody [012] - ab21210 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 012

Anti-Factor VIII antibody - ab139391 from Abcam

Prices $376.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human skeletal muscle and capillaries labeling Factor VIII with ab139391 at 5 µg/ml.

Anti-Factor VIII antibody - ab61910 from Abcam

Prices $370.00
Sizes 100 µl
Host Chicken
Clonality Polyclonal

Anti-Factor VIII antibody - ab61370 from Abcam

Prices $370.00
Sizes 1 mg
Host Sheep
Clonality Polyclonal

Anti-Factor VIII antibody [101] - ab20721 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 101

Anti-Factor VIII antibody [104] - ab20837 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 104
ICC/IF image of ab20837 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab20837 at 1/100 dilution overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- mouse (ab96879) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Factor VIII antibody [2.2.32] - ab41187 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2.2.32
ICC/IF image of ab41187 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab41187 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- mouse (ab96879) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Factor VIII antibody [2.2.9] - ab41186 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2.2.9
IHC image of Factor VIII staining in Human normal liver formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab41186, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Factor VIII antibody [27.4] - ab41188 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 27.4

Anti-Factor VIII antibody [GMA-012] - ab78852 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone GMA-012
Anti-Factor VIII antibody [GMA-012] (ab78852) at 1 µg/ml + human Factor VIII at 2 µgSecondaryGoat anti-mouse HRP conjugated IgG
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