SGPL1

Gene Symbol SGPL1
Entrez Gene 8879
Alt Symbol S1PL, SPL
Species Human
Gene Type protein-coding
Description sphingosine-1-phosphate lyase 1
Other Description SP-lyase 1|SPL 1|hSPL|sphingosine-1-phosphate aldolase
Swissprots Q7Z732 Q9ULG8 O95470 B2RBD4 Q9UN89
Accessions CAM35395 EAW54414 O95470 AB033078 BAA86566 AF144638 AAD44755 AJ011304 CAA09590 AK023873 AK308610 AK314615 BAG37181 BC031338 BC041567 BC051238 BC052991 AAH52991 BC068061 BP314104 XM_005270263 XP_005270320 XM_006718053 XP_006718116 XM_011540316 XP_011538618 XM_011540317 XP_011538619 XM_011540318 XP_011538620 XM_011540319 XP_011538621 NM_003901 NP_003892
Function Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. {ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:14570870, ECO:0000269|PubMed:24809814}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Tissue Specificity Found in liver and kidney. {ECO:0000269|PubMed:11018465}.
Top Pathways Sphingolipid signaling pathway, Sphingolipid metabolism

SP-lyase (H-300) - sc-67368 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SP-lyase (H-300): sc-67368. Western blot analysis of SP-lyase expression in HUV-EC-C whole cell lysate.

SP-lyase (E-19) - sc-51429 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SP-lyase (V-1SP-lyase (E-19) P5) - sc-51432 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SP-lyase (T-20) - sc-51431 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SGPL1 antibody - ab105183 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SGPL1 antibody (ab105183) at 1 µg/mlLane 1 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 3 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lane 4 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SGPL1 antibody - ab169617 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SGPL1 antibody (ab169617) at 1 µg/mlLane 1 : SGPL1 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-SGPL1 antibody - C-terminal - ab198804 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling SGPL1 with ab198804 at 1/25 dilution.

Anti-SGPL1 Antibody (aa79-109, AP) - LS-C240713 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGPL1 Antibody (aa79-109, Biotin) - LS-C240714 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGPL1 Antibody (aa79-109, FITC) - LS-C240716 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGPL1 Antibody (aa79-109, APC) - LS-C240715 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGPL1 Antibody (aa79-109, Azide-free, HRP) - LS-C248143 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGPL1 Antibody (aa79-109, PE) - LS-C240717 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGPL1 Antibody (aa239-493, Biotin) - LS-C297351 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SGPL1 Antibody (aa239-493, FITC) - LS-C302752 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SGPL1 Antibody (aa483-532) - LS-C152139 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SGPL1 antibody Western Blot of 721_B.

Anti-SGPL1 Antibody (aa79-109) - LS-C325068 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGPL1 Antibody (aa239-493) - LS-C296484 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SGPL1.

Anti-SGPL1 Antibody (C-Terminus) - LS-C47069 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SGPL1 Antibody (aa72-101) IHC-plus™ - LS-B10679 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-SGPL1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10679 dilution 1:75.

SGPL1 Antibody [Unconjugated] - AF5535 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of HEK293 human embryonic kidney cell line, HepG2 human hepatocellular carcinoma cell line, HT‑29 human colon adenocarcinoma cell line, and HT‑29 tumor tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human SGPL1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5535) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for SGPL1 at approximately 60 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

SGPL1 Antibody - H00008879-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: SGPL1 Antibody [H00008879-A01]

SGPL1 Antibody - H00008879-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: SGPL1 Antibody [H00008879-D01P] - Analysis of SGPL1 expression in transfected 293T cell line by SGPL1 polyclonal antibody.Lane 1: SGPL1 transfected lysate(63.50 KDa).Lane 2: Non-transfected lysate.

SGPL1 Antibody - H00008879-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: SGPL1 Antibody [H00008879-B01P] - Analysis of SGPL1 expression in transfected 293T cell line by SGPL1 polyclonal antibody. Lane 1: SGPL1 transfected lysate(62.48 KDa). Lane 2: Non-transfected lysate.

SGPL1 Polyclonal Antibody - bs-4188R from Bioss

Prices $279.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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