Gene Symbol | SGPL1 |
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Entrez Gene | 8879 |
Alt Symbol | S1PL, SPL |
Species | Human |
Gene Type | protein-coding |
Description | sphingosine-1-phosphate lyase 1 |
Other Description | SP-lyase 1|SPL 1|hSPL|sphingosine-1-phosphate aldolase |
Swissprots | Q7Z732 Q9ULG8 O95470 B2RBD4 Q9UN89 |
Accessions | CAM35395 EAW54414 O95470 AB033078 BAA86566 AF144638 AAD44755 AJ011304 CAA09590 AK023873 AK308610 AK314615 BAG37181 BC031338 BC041567 BC051238 BC052991 AAH52991 BC068061 BP314104 XM_005270263 XP_005270320 XM_006718053 XP_006718116 XM_011540316 XP_011538618 XM_011540317 XP_011538619 XM_011540318 XP_011538620 XM_011540319 XP_011538621 NM_003901 NP_003892 |
Function | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. {ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:14570870, ECO:0000269|PubMed:24809814}. |
Subcellular Location | Endoplasmic reticulum membrane; Single-pass type III membrane protein. |
Tissue Specificity | Found in liver and kidney. {ECO:0000269|PubMed:11018465}. |
Top Pathways | Sphingolipid signaling pathway, Sphingolipid metabolism |
SP-lyase CRISPR/Cas9 KO Plasmid (h) - sc-402278 from Santa Cruz Biotechnology
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SP-lyase HDR Plasmid (h) - sc-402278-HDR from Santa Cruz Biotechnology
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SP-lyase Double Nickase Plasmid (h) - sc-402278-NIC from Santa Cruz Biotechnology
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SP-lyase Double Nickase Plasmid (h2) - sc-402278-NIC-2 from Santa Cruz Biotechnology
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SP-lyase CRISPR Activation Plasmid (h) - sc-402278-ACT from Santa Cruz Biotechnology
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SP-lyase CRISPR Activation Plasmid (h2) - sc-402278-ACT-2 from Santa Cruz Biotechnology
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SP-lyase Lentiviral Activation Particles (h) - sc-402278-LAC from Santa Cruz Biotechnology
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SP-lyase Lentiviral Activation Particles (h2) - sc-402278-LAC-2 from Santa Cruz Biotechnology
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SP-lyase siRNA (h) - sc-72291 from Santa Cruz Biotechnology
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SP-lyase shRNA Plasmid (h) - sc-72291-SH from Santa Cruz Biotechnology
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SP-lyase shRNA (h) Lentiviral Particles - sc-72291-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU050501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19235 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19235 from Sigma-Aldrich
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SGPL1 siRNA (Human) - CRH5866 from Cohesion Biosciences
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SGPL1 RNAi - H00008879-R01 from Novus Biologicals
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SGPL1 - MBS8224505 from MyBioSource
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shRNA set against Human Sgpl1 (NM_003901.3) - SHH406352 from Creative biogene
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Human SGPL1 siRNA - orb266368 from Biorbyt
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SGPL1 shRNA Plasmid (Human) - CHH5866 from Cohesion Biosciences
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SGPL1 miRNA 3'UTR clone - MiUTR4H-TG08012 from Creative biogene
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