SGPL1

Gene Symbol SGPL1
Entrez Gene 8879
Alt Symbol S1PL, SPL
Species Human
Gene Type protein-coding
Description sphingosine-1-phosphate lyase 1
Other Description SP-lyase 1|SPL 1|hSPL|sphingosine-1-phosphate aldolase
Swissprots Q7Z732 Q9ULG8 O95470 B2RBD4 Q9UN89
Accessions CAM35395 EAW54414 O95470 AB033078 BAA86566 AF144638 AAD44755 AJ011304 CAA09590 AK023873 AK308610 AK314615 BAG37181 BC031338 BC041567 BC051238 BC052991 AAH52991 BC068061 BP314104 XM_005270263 XP_005270320 XM_006718053 XP_006718116 XM_011540316 XP_011538618 XM_011540317 XP_011538619 XM_011540318 XP_011538620 XM_011540319 XP_011538621 NM_003901 NP_003892
Function Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. {ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:14570870, ECO:0000269|PubMed:24809814}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Tissue Specificity Found in liver and kidney. {ECO:0000269|PubMed:11018465}.
Top Pathways Sphingolipid signaling pathway, Sphingolipid metabolism

SP-lyase CRISPR/Cas9 KO Plasmid (h) - sc-402278 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SP-lyase HDR Plasmid (h) - sc-402278-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SP-lyase Double Nickase Plasmid (h) - sc-402278-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SP-lyase Double Nickase Plasmid (h2) - sc-402278-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SP-lyase CRISPR Activation Plasmid (h) - sc-402278-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SP-lyase CRISPR Activation Plasmid (h2) - sc-402278-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SP-lyase Lentiviral Activation Particles (h) - sc-402278-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SP-lyase Lentiviral Activation Particles (h2) - sc-402278-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SP-lyase siRNA (h) - sc-72291 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SP-lyase shRNA Plasmid (h) - sc-72291-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SP-lyase shRNA (h) Lentiviral Particles - sc-72291-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU050501 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19235 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19235 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SGPL1 siRNA (Human) - CRH5866 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SGPL1 RNAi - H00008879-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

SGPL1 - MBS8224505 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Sgpl1 (NM_003901.3) - SHH406352 from Creative biogene

Category siRNA
Species Reactivities Human

Human SGPL1 siRNA - orb266368 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SGPL1 shRNA Plasmid (Human) - CHH5866 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SGPL1 miRNA 3'UTR clone - MiUTR4H-TG08012 from Creative biogene

Species Reactivities Human
Search more