FZD2

Gene Symbol FZD2
Entrez Gene 2535
Alt Symbol Fz2, fz-2, fzE2, hFz2
Species Human
Gene Type protein-coding
Description frizzled class receptor 2
Other Description frizzled 2, seven transmembrane spanning receptor|frizzled family receptor 2|frizzled homolog 2|frizzled-2
Swissprots Q14332 Q0VG82
Accessions EAW51591 Q14332 AB017364 BAA34667 AI376463 AW023425 BC052266 AAH52266 BC113402 AAI13403 BC113404 AAI13405 CN417837 L37882 AAB46397 NM_001466 NP_001457
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular Location Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver.
Top Pathways Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

frizzled (C-17) - sc-7429 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
frizzled (C-17): sc-7429. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes.

frizzled (H-300) - sc-9169 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

frizzled-1 (E-7) - sc-398082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
frizzled-1 (E-7): sc-398082. Western blot analysis of frizzled-1 expression in HeLa (A) and Hep G2 (B) whole cell lysates.

frizzled-2 (C-10) - sc-68327 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

frizzled-2 (E-12) - sc-68328 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
frizzled-2 (E-12): sc-68328. Western blot analysis of frizzled-2 expression in non-transfected 293T: sc-117752 (A), mouse frizzled-2 transfected 293T: sc-125348 (B) and MDA-MB-231 (C) whole cell lysates.

frizzled-2 (G-19) - sc-68329 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

frizzled-2 (S-13) - sc-68330 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Frizzled 2 antibody - ab109094 from Abcam

Prices $378.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
ICC/IF image of ab109094 stained A549 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA, 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells. The cells were then incubated with the antibody ab109094 at 10µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 donkey anti- goat (ab96931) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Frizzled 2 antibody - ab52565 from Abcam

Prices $372.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Frizzled 2 antibody - ab58145 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab58145 Frizzled 2 antibody at 1ug/ml.

Anti-Frizzled 2 antibody - ab94913 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Frizzled 2 antibody (ab94913) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal spleen lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Frizzled 2 antibody - ab123692 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Frizzled 2 antibody (ab123692) at 1/100 dilution + MDA-MB-231 cell lysate at 35 µg

Anti-Frizzled 2 antibody - N-terminal - ab150477 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human fetal kidney tissue labelling Frizzled 2 with ab150477 antibody at a concentration of 8 µg/ml.

Anti-FZD2 / Frizzled 2 Antibody (Extracellular Domain) IHC-plus™ - LS-A3488 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FSD2 / Frizzled 2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-FZD2 / Frizzled 2 Antibody (N-Terminus) IHC-plus™ - LS-A3491 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FSD2 / Frizzled 2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-FZD2 / Frizzled 2 Antibody (N-Terminus) - LS-C6902 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FZD2 / Frizzled 2 Antibody (aa533-563, AP) - LS-C207065 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD2 / Frizzled 2 Antibody (aa533-563, APC) - LS-C207066 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD2 / Frizzled 2 Antibody (aa533-563, Biotin) - LS-C207067 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD2 / Frizzled 2 Antibody (aa533-563, FITC) - LS-C207068 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD2 / Frizzled 2 Antibody (aa533-563, Azide-free, HRP) - LS-C207069 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD2 / Frizzled 2 Antibody (aa533-563, PE) - LS-C207070 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD2 / Frizzled 2 Antibody (aa533-563) - LS-C321496 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD2 / Frizzled 2 Antibody (aa191-240) - LS-C291962 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FZD2 / Frizzled 2 Antibody (N-Terminus) - LS-C110618 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FZD2 / Frizzled 2 antibody LS-C110618 Western blot of Fetal Spleen lysate.
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