| Gene Symbol |
FZD2
|
| Entrez Gene |
2535
|
| Alt Symbol |
Fz2, fz-2, fzE2, hFz2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
frizzled class receptor 2
|
| Other Description |
frizzled 2, seven transmembrane spanning receptor|frizzled family receptor 2|frizzled homolog 2|frizzled-2
|
| Swissprots |
Q14332 Q0VG82
|
| Accessions |
EAW51591 Q14332 AB017364 BAA34667 AI376463 AW023425 BC052266 AAH52266 BC113402 AAI13403 BC113404 AAI13405 CN417837 L37882 AAB46397 NM_001466 NP_001457
|
| Function |
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver.
|
| Top Pathways |
Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway
|