SPAM1

Gene Symbol	SPAM1
Entrez Gene	6677
Alt Symbol	HEL-S-96n, HYA1, HYAL1, HYAL3, HYAL5, PH-20, PH20, SPAG15
Species	Human
Gene Type	protein-coding
Description	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
Other Description	epididymis secretory sperm binding protein Li 96n|hyal-PH20|hyaluronidase PH-20|hyaluronoglucosaminidase PH-20|sperm surface protein PH-20
Swissprots	P38567 Q8TC30
Accessions	AAQ96882 CBH19453 CBL54474 CBL86562 CCA64576 CCD32726 CCF70987 EAL24329 EAL24330 EAW83604 EAW83605 EAW83606 P38567 AK292229 BAF84918 AY920278 AAX13985 AY920279 AAX13986 AY920280 AAX13987 AY920281 AAX13988 BC026163 AAH26163 BI831525 DB023094 DQ891657 ABM82583 DQ894844 ABM85770 EU794686 ACJ13740 L13779 L13781 S67798 AAC60607 X84347 CAA59086 XM_011516523 XP_011514825 XM_011516524 XP_011514826 XM_011516525 XP_011514827 XM_011516526 XP_011514828 NM_001174044 NP_001167515 NM_001174045 NP_001167516 NM_001174046 NP_001167517 NM_003117 NP_003108 NM_153189 NP_694859
Function	Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. {ECO:0000269|PubMed:8282124}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity	Testis. {ECO:0000269|PubMed:8234258}.
Top Pathways	Glycosaminoglycan degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Hyaluronidase PH20 full length protein - ab132258 from Abcam Category Protein Source Wheat germ Species Human

Human Hyaluronidase PH20 protein fragment - ab114725 from Abcam Category Protein Source Wheat germ Species Human

Human Hyaluronidase PH20 protein fragment - ab174000 from Abcam Category Protein Source HEK 293 cells Species Human

SPAM1 / PH20 Blocking Peptide - LS-E6312 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPAM1 / PH20 Antibody Blocking Peptide - LS-E23431 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SPAM1 Protein - H00006677-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human SPAM1 Protein - H00006677-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

SPAM1-Antibody-C-term-Blocking-Peptide - BP19001b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human SPAM1 protein - orb246441 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

SPAM1 - H00006677-P01-02 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SPAM1 - H00006677-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SPAM1 - H00006677-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PH20 Hyaluronidase Recombinant Protein - 96-626 from ProSci Category Protein Prices $450.00 Sizes 25 µg Source HEK293 cells Species Human

SPAM1 fusion protein - ag1682 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Hyaluronidase PH-20 - SPAM1-P1004H from Creative Biomart Category Protein Source ChineseHamster Ovary (CHO cell)

Recombinant Human SPAM1, His-Fc-tagged - SPAM1-1532H from Creative Biomart Category Protein Source Human

Recombinant Human SPAM1, His-tagged - SPAM1-738H from Creative Biomart Category Protein Source HEK293 Species Human

Human SPAM1 (PH-20) Recombinant - RKP38567 from Reprokine Category Protein Prices $160.00, $680.00, $1,950.00 Sizes 5 µg, 25 µg, 100 µg Source Optimized DNA sequence encoding extracellular domain of human SPAM1 (PH20) (LEU 36 - TYR482 ) including a C-terminal His tag was expressed in HEK293 cells. Species Human

Human PH20 / SPAM1 Protein - PH0-H5225 from ACROBiosystems Category Protein Prices $315.00, $1,250.00 Sizes 25 µg, 200 µg Source Human PH20, His Tag (PH0-H5225) is expressed from human 293 cells (HEK293). It contains AA Leu 36 - Tyr 482 (Accession # AAH26163). Species Human

Recombinant human Hyaluronidase PH-20 - CSB-EP022471HU CSB-BP022471HU CSB-MP022471HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant human Hyaluronidase PH-20 - CSB-YP022471HU from Cusabio Category Protein Source E.coli Species Human

Recombinant Human Hyaluronidase PH-20(SPAM1) - CSB-YP022471HU CSB-EP022471HU CSB-BP022471HU CSB-MP022471HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Human CellExp™ SPAM1, human recombinant - 7247-10 from Biovision Category Protein Prices $305.00 Sizes 10 μg Source HEK 293 cells Species Human

Human CellExp™ SPAM1, human recombinant - 7247-50 from Biovision Category Protein Prices $995.00 Sizes 50 μg Source HEK 293 cells Species Human

SPAM1 (transcript variant 1) - TP305378 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Search more