Gene Symbol | ZNF516 |
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Entrez Gene | 9658 |
Alt Symbol | HsT287 |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger protein 516 |
Other Description | - |
Swissprots | Q92618 |
Accessions | EAW66578 Q92618 BC108287 AAI08288 BC113085 BC113086 BC128041 D16475 D86975 BAA13211 XM_011526269 XP_011524571 XM_011526270 XP_011524572 XM_011526271 XP_011524573 XM_011526272 XP_011524574 XM_011526273 XP_011524575 XM_011526274 XP_011524576 XM_011526275 XP_011524577 XM_011526276 XP_011524578 XM_011526277 XP_011524579 XR_935268 NM_014643 NP_055458 |
Function | Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422). {ECO:0000250|UniProtKB:Q7TSH3, ECO:0000269|PubMed:23446422}. |
Subcellular Location | Nucleus {ECO:0000250|UniProtKB:Q7TSH3}. |
ZNF516 CRISPR/Cas9 KO Plasmid (h) - sc-405422 from Santa Cruz Biotechnology
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ZNF516 HDR Plasmid (h) - sc-405422-HDR from Santa Cruz Biotechnology
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ZNF516 Double Nickase Plasmid (h) - sc-405422-NIC from Santa Cruz Biotechnology
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ZNF516 Double Nickase Plasmid (h2) - sc-405422-NIC-2 from Santa Cruz Biotechnology
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ZNF516 CRISPR Activation Plasmid (h) - sc-405422-ACT from Santa Cruz Biotechnology
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ZNF516 CRISPR Activation Plasmid (h2) - sc-405422-ACT-2 from Santa Cruz Biotechnology
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ZNF516 Lentiviral Activation Particles (h) - sc-405422-LAC from Santa Cruz Biotechnology
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ZNF516 Lentiviral Activation Particles (h2) - sc-405422-LAC-2 from Santa Cruz Biotechnology
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ZNF516 siRNA (h) - sc-76992 from Santa Cruz Biotechnology
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ZNF516 shRNA Plasmid (h) - sc-76992-SH from Santa Cruz Biotechnology
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ZNF516 shRNA (h) Lentiviral Particles - sc-76992-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU021871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23507 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23507 from Sigma-Aldrich
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ZNF516 siRNA (Human) - CRH6435 from Cohesion Biosciences
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ZNF516 - MBS827367 from MyBioSource
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shRNA set against Human ZNF516 (NM_014643.3) - SHH454224 from Creative biogene
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Human ZNF516 siRNA - orb266937 from Biorbyt
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ZNF516 shRNA Plasmid (Human) - CHH6435 from Cohesion Biosciences
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ZNF516 miRNA 3'UTR clone - MiUTR4H-TG10269 from Creative biogene
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