TRAF4

Gene Symbol TRAF4
Entrez Gene 9618
Alt Symbol CART1, MLN62, RNF83
Species Human
Gene Type protein-coding
Description TNF receptor-associated factor 4
Other Description MLN 62|RING finger protein 83|cysteine-rich domain associated with RING and Traf domains protein 1|cysteine-rich domain associated with ring and TRAF domain|malignant 62|metastatic lymph node gene 62 protein|tumor necrosis receptor-associated factor 4A
Swissprots Q14848 Q2PJN8 Q2KJU4 O75615 Q9BUZ4
Accessions ABC40750 EAW51138 EAW51139 EAW51140 EAW51141 EAW51142 Q9BUZ4 AF082185 AAC32376 AK300804 BAG62461 AY937222 AAY16988 AY937223 AAY16989 AY937224 AAY16990 AY937225 AAY16991 BC001769 AAH01769 BC026726 BC047358 CR990949 DQ892825 ABM83751 DQ896071 ABM87070 X80200 CAA56491 XM_011525504 XP_011523806 XM_011525505 XP_011523807 XM_011525506 XP_011523808 XM_011525507 XP_011523809 XM_011525508 XP_011523810 NM_004295 NP_004286 NM_145751
Function Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. {ECO:0000250, ECO:0000269|PubMed:12023963, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:16052631, ECO:0000269|PubMed:16157600, ECO:0000269|PubMed:18953416, ECO:0000269|PubMed:19937093}.
Subcellular Location Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton {ECO:0000305}.
Tissue Specificity Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus. {ECO:0000269|PubMed:7592751, ECO:0000269|PubMed:9626059}.
Top Pathways Small cell lung cancer

TRAF4 (D-2) - sc-390212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRAF4 (D-2): sc-390212. Western blot analysis of TRAF4 expression in SK-BR-3 nuclear extract.

TRAF4 (B-9) - sc-390232 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRAF4 (B-9): sc-390232. Western blot analysis of TRAF4 expression in SK-BR-3 whole cell lysate.

TRAF4 (N-16) - sc-1921 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRAF4 (N-16): sc-1921. Western blot analysis of TRAF4 expression in phorbol ester-treated A-431 nuclear extract (A), SK-BR-3 whole cell lysate (B) and SK-BR-3 nuclear extract (C).

TRAF4 (H-72) - sc-10776 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRAF4 (H-72): sc-10776. Western blot analysis of TRAF4 expression in HeLa (A), A-431 (B) and SK-BR-3 (C) whole cell lysates and PMA-treated A-431 (D) and SK-BR-3 (E) nuclear extracts.

TRAF4 (C-20) - sc-1920 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRAF4 (C-20): sc-1920. Western blot analysis of TRAF4 expression in HeLa whole cell lysate.

TRAF4 (43) - sc-136107 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
TRAF4 (43): sc-136107. Western blot analysis of TRAF4 expression in Jurkat whole cell lysate.

Anti-TRAF4 antibody - ab88612 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-TRAF4 antibody (ab88612) at 1 µg/ml + human pancreas tissue lysate at 50 µg

Anti-TRAF4 antibody - ab56613 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
TRAF4 antibody (ab56613) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human salivary gland.

Anti-TRAF4 antibody - ab83227 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TRAF4 antibody (ab83227) at 1 µg/ml (in 5% skim milk / PBS buffer) + Hela cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-TRAF4 antibody - ab81476 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRAF4 antibody - ab124246 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TRAF4 antibody (ab124246) at 1/100 dilution + HepG2 cell line lysates at 35 µg

Anti-TRAF4 antibody - ab137203 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TRAF4 antibody (ab137203) at 1/500 dilution + K562 cell lysate at 30 µg

Anti-TRAF4 antibody [EPR1729] - ab108991 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1729
Overlay histogram showing HeLa cells stained with ab108991 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab108991, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-TRAF4 antibody - C-terminal - ab190986 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TRAF4 antibody - C-terminal (ab190986) at 0.5 µg/mlLane 1 : Rat thymus lysateLane 2 : HeLa lysateLane 3 : Jurkat lysateLane 4 : Hepa lysate

Anti-TRAF4 Antibody (aa437-454) - LS-C313139 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
CART1 / TRAF4 antibody. IHC(P): Human Lung Cancer Tissue.

Anti-TRAF4 Antibody (aa1-18) - LS-C10905 from LifeSpan Bioscience

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-TRAF4 Antibody (N-Terminus) - LS-C145013 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRAF4 Antibody (aa1-17) - LS-C148301 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-TRAF4 Antibody (Leu302) - LS-C193271 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRAF4 Antibody (aa427-455, Biotin) - LS-C242064 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRAF4 Antibody (aa427-455, APC) - LS-C242065 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRAF4 Antibody (aa427-455, AP) - LS-C242066 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRAF4 Antibody (aa427-455, FITC) - LS-C242067 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRAF4 Antibody (aa427-455, PE) - LS-C242071 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRAF4 Antibody (aa427-455, Azide-free, HRP) - LS-C247119 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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