| Gene Symbol |
TRAF4
|
| Entrez Gene |
9618
|
| Alt Symbol |
CART1, MLN62, RNF83
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TNF receptor-associated factor 4
|
| Other Description |
MLN 62|RING finger protein 83|cysteine-rich domain associated with RING and Traf domains protein 1|cysteine-rich domain associated with ring and TRAF domain|malignant 62|metastatic lymph node gene 62 protein|tumor necrosis receptor-associated factor 4A
|
| Swissprots |
Q14848 Q2PJN8 Q2KJU4 O75615 Q9BUZ4
|
| Accessions |
ABC40750 EAW51138 EAW51139 EAW51140 EAW51141 EAW51142 Q9BUZ4 AF082185 AAC32376 AK300804 BAG62461 AY937222 AAY16988 AY937223 AAY16989 AY937224 AAY16990 AY937225 AAY16991 BC001769 AAH01769 BC026726 BC047358 CR990949 DQ892825 ABM83751 DQ896071 ABM87070 X80200 CAA56491 XM_011525504 XP_011523806 XM_011525505 XP_011523807 XM_011525506 XP_011523808 XM_011525507 XP_011523809 XM_011525508 XP_011523810 NM_004295 NP_004286 NM_145751
|
| Function |
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. {ECO:0000250, ECO:0000269|PubMed:12023963, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:16052631, ECO:0000269|PubMed:16157600, ECO:0000269|PubMed:18953416, ECO:0000269|PubMed:19937093}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton {ECO:0000305}.
|
| Tissue Specificity |
Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus. {ECO:0000269|PubMed:7592751, ECO:0000269|PubMed:9626059}.
|
| Top Pathways |
Small cell lung cancer
|
