Gene Symbol | ACOT1 |
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Entrez Gene | 641371 |
Alt Symbol | ACH2, CTE-1, LACH2 |
Species | Human |
Gene Type | protein-coding |
Description | acyl-CoA thioesterase 1 |
Other Description | CTE-I|CTE-Ib|acyl-coenzyme A thioesterase 1|inducible cytosolic acyl-coenzyme A thioester hydrolase|long chain acyl-CoA hydrolase|long chain acyl-CoA thioester hydrolase |
Swissprots | Q86TX2 A1L173 Q3I5F9 |
Accessions | Q86TX2 AK300886 BAG62528 BC127747 AAI27748 BC127748 AAI27749 BC132889 AAI32890 BC132891 AAI32892 BC143042 AAI43043 BC144425 AAI44426 BX161396 CAD61883 DQ082754 AAZ31236 GU727640 ADU87641 XM_011537075 XP_011535377 NM_001037161 NP_001032238 |
Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16940157}. |
Top Pathways | Fatty acid elongation, Biosynthesis of unsaturated fatty acids |
ACOT1 CRISPR/Cas9 KO Plasmid (h) - sc-416095 from Santa Cruz Biotechnology
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ACOT1 HDR Plasmid (h) - sc-416095-HDR from Santa Cruz Biotechnology
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ACOT1 Double Nickase Plasmid (h) - sc-416095-NIC from Santa Cruz Biotechnology
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ACOT1 Double Nickase Plasmid (h2) - sc-416095-NIC-2 from Santa Cruz Biotechnology
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ACOT1 CRISPR Activation Plasmid (h) - sc-416095-ACT from Santa Cruz Biotechnology
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ACOT1 CRISPR Activation Plasmid (h2) - sc-416095-ACT-2 from Santa Cruz Biotechnology
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ACOT1 Lentiviral Activation Particles (h) - sc-416095-LAC from Santa Cruz Biotechnology
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ACOT1 Lentiviral Activation Particles (h2) - sc-416095-LAC-2 from Santa Cruz Biotechnology
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ACOT1 siRNA (h) - sc-72433 from Santa Cruz Biotechnology
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ACOT1 shRNA Plasmid (h) - sc-72433-SH from Santa Cruz Biotechnology
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ACOT1 shRNA (h) Lentiviral Particles - sc-72433-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN2724 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2724 from Sigma-Aldrich
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ACOT1 siRNA (Human) - CRJ8422 from Cohesion Biosciences
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ACOT1 - MBS8233228 from MyBioSource
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shRNA set against Human Acot1 (NM_001037161.1) - SHH230362 from Creative biogene
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shRNA set against Human ACOT1(NM_001037161.1) - SHG029939 from Creative biogene
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ACOT1 shRNA Plasmid (Human) - CHJ8422 from Cohesion Biosciences
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ACOT1 miRNA 3'UTR clone - MiUTR1H-00106 from Creative biogene
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