Gene Symbol | CDC16 |
---|---|
Entrez Gene | 8881 |
Alt Symbol | ANAPC6, APC6, CUT9 |
Species | Human |
Gene Type | protein-coding |
Description | cell division cycle 16 |
Other Description | CDC16Hs|anaphase-promoting complex subunit 6|anaphase-promoting complex, subunit 6|cell division cycle 16 homolog|cell division cycle protein 16 homolog|cyclosome subunit 6 |
Swissprots | Q9Y564 Q13042 Q96AE6 Q7Z651 Q5T8C8 A2A365 |
Accessions | AAS94323 CCQ43240 EAX09237 EAX09238 EAX09239 EAX09240 EAX09241 EAX09242 EAX09243 EAX09244 EAX09245 Q13042 AB209850 BAD93087 AF164598 AAD45156 AK095082 AK296424 BAG59086 AK315302 BAG37707 AL540490 BC010875 AAH10875 BC017244 AAH17244 BC050575 U18291 AAC50200 XM_005266204 XP_005266261 XM_005266206 XP_005266263 XM_006719992 XP_006720055 XM_006719993 XP_006720056 XM_011534851 XP_011533153 XM_011534852 XP_011533154 XM_011534853 XP_011533155 XR_245358 XR_245359 XR_245360 XR_941424 NM_001078645 NP_001072113 NM_003903 NP_003894 |
Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}. |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:7736578}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:7736578}. Note=Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle. |
Top Pathways | Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection |