| Gene Symbol |
AIFM3
|
| Entrez Gene |
150209
|
| Alt Symbol |
AIFL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apoptosis-inducing factor, mitochondrion-associated, 3
|
| Other Description |
apoptosis-inducing factor 3|apoptosis-inducing factor like
|
| Swissprots |
Q8N5E0 Q6ZT44 D3DX38 Q8N1V3 D3DX37 B7WP37 Q96NN9
|
| Accessions |
EAX02924 EAX02925 EAX02926 EAX02927 EAX02928 EAX02929 EAX02930 EAX02931 Q96NN9 AK055035 BAB70841 AK094844 BAC04434 AK126917 AK295581 BAH12112 AK316042 BAH14413 AY927574 AY927594 BC032485 AAH32485 BQ028401 CR456342 CAG30228 CU013053 CAK54484 CU013341 CAK54783 DA396585 DB172173 JF432230 ADZ15447 NM_001018060 NP_001018070 NM_001146288 NP_001139760 NM_144704 NP_653305 NR_027464
|
| Function |
Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential. {ECO:0000269|PubMed:15764604}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:15764604}. Note=Does not translocate to the nucleus upon induction of apoptosis.
|
| Tissue Specificity |
Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland and tongue (at protein level). {ECO:0000269|PubMed:15764604}.
|
![Western Blot: AIFM3 Overexpression Lysate (Adult Normal) [NBL1-07412] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AIFM3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7858_AIFM3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07412-img0002.jpg)