HMGCL

Gene Symbol	HMGCL
Entrez Gene	3155
Alt Symbol	HL
Species	Human
Gene Type	protein-coding
Description	3-hydroxymethyl-3-methylglutaryl-CoA lyase
Other Description	3-hydroxy-3-methylglutarate-CoA lyase|3-hydroxy-3-methylglutaryl-CoA lyase|3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase|HMG-CoA lyase|hydroxymethylglutaricaciduria|hydroxymethylglutaryl-CoA lyase, mitochondrial|mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase
Swissprots	Q96FP8 B7UCC6 D3Y5K7 B4DUP4 P35914 Q6IBC0
Accessions	AER36554 EAW95094 EAW95095 EAW95096 EAW95097 P35914 AI202943 AK122801 BAG53736 AK300733 BAG62406 AK309129 AK313869 BAG36597 BC010570 AAH10570 BC021145 BM981610 BT009792 AAP88794 CA306929 CR456884 CAG33165 DA425822 DQ892083 ABM83009 DQ895276 ABM86202 FJ472654 ACK58684 GU433941 ADD21697 L07033 AAA92733 NM_000191 NP_000182 NM_001166059 NP_001159531
Function	Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. {ECO:0000269|PubMed:22847177, ECO:0000269|PubMed:22865860, ECO:0000269|PubMed:8566388}.
Subcellular Location	Mitochondrion matrix. Peroxisome. Note=Unprocessed form is peroxisomal.
Tissue Specificity	Highest expression in liver. Expressed in pancreas, kidey, intestine, testis, fibroblasts and lymphoblasts. Very low expression in brain and skeletal muscle. The relative expression of isoform 2 (at mRNA level) is highest in heart (30%), skeletal muscle (22%), and brain (14%). {ECO:0000269|PubMed:21952825}.
Top Pathways	Peroxisome, Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Lipase, Hepatic (LIPC), Human, ELISA Kit - SEA769Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 35pg/mL Range 78-5,000pg/mL

HMGCL (Human) IP-WB Antibody Pair - H00003155-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

HMGCL (Human) Matched Antibody Pair - H00003155-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human HL ELISA Kit - HH0260 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine HL ELISA Kit - AH0260 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase, ELISA Kit - MBS9333082 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Hepatic lipase ELISA - E01H0253 from BlueGene Biotech Category ELISA Kit Sensitivity 0.1 ng/mL

ELISA Kit for Lipase, Hepatic (LIPC) - SEA769Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 33pg/mL. Range 78.125-5000pg/mL The standard curve concentrations used for the ELISA's were 5000pg/mL, 2500pg/mL, 1250pg/mL, 625pg/mL, 312.5pg/mL, 156.25pg/mL, 78.125pg/mL

Human LIPC(Lipase, Hepatic) ELISA Kit - E-EL-H0478 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mLng/mL Range 0.16~10 ng/mL

Human LIPH (Lipase H) CLIA Kit - E-CL-H0353 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 0.938ng/mL Range 1.563-100ng/mL

Lipase, Hepatic (LIPC), Human, ELISA Kit - DL-LIPC-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 78-5,000 pg/mL

Human HL ELISA Kit - E018313 from Biobool Category ELISA Kit Sensitivity 0.06 ng/ml.

Human HMGCL ELISA Kit - E041932 from Biobool Category ELISA Kit

Human HL ELISA Kit - EHH0260 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

anti-HMGCL antibody - ARG56393 from Arigo Biolaboratories Category ELISA Kit

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