TDRD9
| Gene Symbol | TDRD9 |
|---|---|
| Entrez Gene | 122402 |
| Alt Symbol | C14orf75, HIG-1, NET54 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tudor domain containing 9 |
| Other Description | hypoxia-inducible HIG-1|putative ATP-dependent RNA helicase TDRD9|tudor domain-containing protein 9 |
| Swissprots | Q96AS9 Q8N9V5 A1A4S7 Q8N7T3 Q8NDG6 Q8N827 Q6ZU54 |
| Accessions | Q8NDG6 AK093483 BAC04182 AK097429 BAC05047 AK097699 BAC05144 AK125978 BAC86372 AL833915 CAD38771 BC016796 AAH16796 BC033662 BC042804 BC128057 AAI28058 BG719020 BU430972 U56244 AAC25432 XM_005267309 XP_005267366 XM_006720019 XP_006720082 XM_006720020 XP_006720083 XM_011536396 XP_011534698 XM_011536397 XP_011534699 XM_011536398 XP_011534700 XM_011536399 XP_011534701 XM_011536400 XP_011534702 XM_011536401 XP_011534703 XM_011536402 XP_011534704 NM_153046 NP_694591 |
| Function | Probable ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with PIWIL4 and the piP-bodies suggests a participation in the secondary piRNAs metabolic process (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies (By similarity). {ECO:0000250}. |
TDRD9 CRISPR/Cas9 KO Plasmid (h) - sc-414178 from Santa Cruz Biotechnology
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TDRD9 HDR Plasmid (h) - sc-414178-HDR from Santa Cruz Biotechnology
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TDRD9 Double Nickase Plasmid (h) - sc-414178-NIC from Santa Cruz Biotechnology
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TDRD9 Double Nickase Plasmid (h2) - sc-414178-NIC-2 from Santa Cruz Biotechnology
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TDRD9 CRISPR Activation Plasmid (h) - sc-414178-ACT from Santa Cruz Biotechnology
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TDRD9 CRISPR Activation Plasmid (h2) - sc-414178-ACT-2 from Santa Cruz Biotechnology
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TDRD9 Lentiviral Activation Particles (h) - sc-414178-LAC from Santa Cruz Biotechnology
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TDRD9 Lentiviral Activation Particles (h2) - sc-414178-LAC-2 from Santa Cruz Biotechnology
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TDRD9 siRNA (h) - sc-92148 from Santa Cruz Biotechnology
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TDRD9 shRNA Plasmid (h) - sc-92148-SH from Santa Cruz Biotechnology
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TDRD9 shRNA (h) Lentiviral Particles - sc-92148-V from Santa Cruz Biotechnology
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TDRD9 RNAi - H00122402-R01 from Novus Biologicals
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MISSION® esiRNA - EHU058971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21192 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21192 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04446 from Sigma-Aldrich
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TDRD9 siRNA (Human) - CRJ4693 from Cohesion Biosciences
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TDRD9 - MBS8219601 from MyBioSource
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shRNA set against Human TDRD9 (NM_153046.2) - SHH425400 from Creative biogene
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TDRD9 shRNA Plasmid (Human) - CHJ4693 from Cohesion Biosciences
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TDRD9 miRNA 3'UTR clone - MiUTR1H-10302 from Creative biogene
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