Gene Symbol | DRC1 |
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Entrez Gene | 92749 |
Alt Symbol | C2orf39, CCDC164, CILD21 |
Species | Human |
Gene Type | protein-coding |
Description | dynein regulatory complex subunit 1 |
Other Description | coiled-coil domain containing 164|coiled-coil domain-containing protein 164|dynein regulatory complex protein 1|dynein regulatory complex subunit 1 homolog |
Swissprots | Q53R91 A8K1N8 Q53TA3 Q96MC2 Q8NDI5 |
Accessions | AAY14647 AAY15082 EAX00688 EAX00689 Q96MC2 AK057222 BAB71385 AK289953 BAF82642 AK307094 AL833892 CAD38748 BC009488 XM_005264637 XP_005264694 XM_005264638 XP_005264695 NM_145038 NP_659475 |
Function | Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending. {ECO:0000269|PubMed:23354437}. |
Subcellular Location | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. |
CCDC164 CRISPR/Cas9 KO Plasmid (h) - sc-413954 from Santa Cruz Biotechnology
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CCDC164 HDR Plasmid (h) - sc-413954-HDR from Santa Cruz Biotechnology
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CCDC164 Double Nickase Plasmid (h) - sc-413954-NIC from Santa Cruz Biotechnology
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CCDC164 Double Nickase Plasmid (h2) - sc-413954-NIC-2 from Santa Cruz Biotechnology
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CCDC164 CRISPR Activation Plasmid (h) - sc-413954-ACT from Santa Cruz Biotechnology
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CCDC164 CRISPR Activation Plasmid (h2) - sc-413954-ACT-2 from Santa Cruz Biotechnology
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CCDC164 Lentiviral Activation Particles (h) - sc-413954-LAC from Santa Cruz Biotechnology
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CCDC164 Lentiviral Activation Particles (h2) - sc-413954-LAC-2 from Santa Cruz Biotechnology
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CCDC164 siRNA (h) - sc-94408 from Santa Cruz Biotechnology
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CCDC164 shRNA Plasmid (h) - sc-94408-SH from Santa Cruz Biotechnology
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CCDC164 shRNA (h) Lentiviral Particles - sc-94408-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU063981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4824 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4824 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01493 from Sigma-Aldrich
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DRC1 siRNA (Human) - CRJ4165 from Cohesion Biosciences
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DRC1 - MBS8231290 from MyBioSource
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shRNA set against Human CCDC164 (NM_145038.2) - SHH256377 from Creative biogene
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Human DRC1 siRNA - orb274666 from Biorbyt
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DRC1 shRNA Plasmid (Human) - CHJ4165 from Cohesion Biosciences
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CCDC164 miRNA 3'UTR clone - MiUTR4H-TG00985 from Creative biogene
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