DDX3X

Gene Symbol DDX3X
Entrez Gene 1654
Alt Symbol CAP-Rf, DBX, DDX14, DDX3, HLP2
Species Human
Gene Type protein-coding
Description DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
Other Description ATP-dependent RNA helicase DDX3X|DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked|DEAD box protein 3, X-chromosomal|DEAD box, X isoform|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3|DEAD/H box-3|helicase-like protein 2
Swissprots O15536 O00571 B4E3E8 A8K538
Accessions EAW59402 EAW59403 EAW59404 EAW59405 O00571 AA481139 AB208983 BAD92220 AB451220 BAG70034 AB451343 BAG70157 AF000982 AAC51829 AF000983 AAC51830 AF061337 AAC34298 AF086430 AI698207 AK127902 AK291153 BAF83842 AK296906 BAG59462 AK297159 BAG59657 AK304661 BAG65436 AK304689 BAG65460 AK310891 AU144400 AY776161 AAV52794 BC007668 BC011819 AAH11819 BC055083 BF980241 BM454841 BM833870 BQ921695 CB107740 DA232063 DB065845 L37696 U50553 AAB95637 XM_011543892 XP_011542194 NM_001193416 NP_001180345 NM_001193417 NP_001180346 NM_001356 NP_001347 NR_126093 NR_126094 NM_024005
Function Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'- single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation. Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5'UTRs; these functions seem to require RNA helicase activit
Subcellular Location Nucleus speckle. Cytoplasm. Mitochondrion outer membrane. Note=Located predominantly in nuclear speckles and, at low levels, throughout the cytoplasm. Located to the outer side of nuclear pore complexes (NPC). Shuttles between the nucleus and the cytoplasm in a XPO1 and may be also in a NFX1-dependent manner. Associated with polyadenylated mRNAs in the cytoplasm and the nucleus. Predominantly located in nucleus during G(0) phase and in the cytoplasm during G1/S phase.
Top Pathways RIG-I-like receptor signaling pathway, Viral carcinogenesis

DDX3 Antibody - 2635 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using DDX3 Antibody.

DDX3 (D19B4) Rabbit mAb - 8192 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D19B4
Western blot analysis of extracts from various cell lines using DDX3 (D19B4) Rabbit mAb.

DDX3 (C-4) - sc-365768 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DDX3 (C-4): sc-365768. Western blot analysis of DDX3 expression in NIH/3T3 (A), A-431 (B), Jurkat (C) and PC-12 (D) nuclear extracts.

DDX3 (H-114) - sc-98711 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DDX3 (H-114): sc-98711. Immunoperoxidase staining of formalin fixed, paraffin-embedded human tonsil tissue showing nuclear and cytoplasmic staining of squamous epithelial cells.

DDX3 (T-18) - sc-74604 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DDX3 (Y-18) - sc-74605 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DDX3 (2253C5a) - sc-81247 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
DDX3 (2253C5a): sc-81247 Western Blot analysis of DDX3 expression in F2408 whole cell lysate.

DDX3X (Q-21) - sc-130736 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
DDX3X (Q-21): sc-130736. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human hepatocarcinoma tissue showing cytoplasmic localization.

Anti-DDX3 (phospho T322) antibody - ab61043 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
1/500-1/1000 ab61043 staining phosphorilated DDX3 on HuvEc cells treated with 20% serum for 30 minutes, only in the absence of the immunizing phosphopeptide.

Anti-DDX3 antibody - ab37160 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-DDX3 antibody (ab37160) at 0.5 µg/mlLane 2 : Anti-DDX3 antibody (ab37160) at 1 µg/mlLane 1 : Human HepG2 cell lysateLane 2 : Human HepG2 cell lysateLysates/proteins at 15 µg per lane.

Anti-DDX3 antibody - ab151965 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DDX3 antibody (ab151965) at 1/2000 dilutionLane 1 : HeLa lysateLane 2 : HeLa cytoplasmic lysateLysates/proteins at 20 µg per lane.

Anti-DDX3 antibody - ab61153 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DDX3 antibody (ab61153) at 1/500 dilutionLane 1 : extracts from HepG2 cellsLane 2 : extracts from HepG2 cells with immunizing peptide

Anti-DDX3 antibody - ab62581 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62581 at 10µg/ml staining DDX3 in HepG2 cells by Immunocytochemistry.

Anti-DDX3 antibody - ab128206 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DDX3 antibody (ab128206) at 1/1000 dilution + HeLa whole cell extracts at 10 µg

Anti-DDX3 antibody - ab188630 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-DDX3 antibody (ab188630) at 0.5 µg/mlLane 2 : Anti-DDX3 antibody (ab188630) at 1 µg/mlLane 1 : HepG2 cell lysateLane 2 : HepG2 cell lysate

Anti-DDX3 antibody - ab140209 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DDX3 antibody (ab140209) at 1/1000 dilution + HepG2 cell lysate

Anti-DDX3 antibody [2253C5a] - ab50703 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2253C5a
Anti-DDX3 antibody [2253C5a] (ab50703) at 1/100 dilution + Hela whole cell lysate at 25 µg

Anti-DDX3 antibody [6G8-F4-E3] - ab196032 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6G8-F4-E3
All lanes : Anti-DDX3 antibody [6G8-F4-E3] (ab196032) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : K562 cell lysateLane 3 : COS7 cell lysateLane 4 : C6 cell lysateLane 5 : 3T3 cell lysateLane 6 : HeLa cell lysate

Anti-DDX3 antibody [IMG11F11D10] - ab138725 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone IMG11F11D10
All lanes : Anti-DDX3 antibody [IMG11F11D10] (ab138725) at 2 µg/mlLane 1 : Partial recombinant Human DDX3 protein (amino acids 24-203)Lane 2 : 293 lysateSecondaryGoat anti-mouse Ig HRP

Anti-DDX3 Antibody (Ser63) - LS-C177420 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of DDX3 (S63) pAb in extracts from Jurkat cells.

Anti-DDX3 / DDX3X Antibody (Leu318) - LS-C176503 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of DDX3 (L318) pAb in paraffin-embedded human brain tissue.

Anti-DDX3 Antibody (aa70-346) - LS-C186094 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of paraformaldehyde-fixed HeLa using DDX3Y antibody at 1:200 dilution.

Anti-DDX3 / DDX3X Antibody (aa550-600) - LS-C64574 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DDX3 / DDX3X Antibody (N-Terminus) - LS-C64572 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DDX3 / DDX3X Antibody - LS-C64576 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
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