DDX3X

Gene Symbol	DDX3X
Entrez Gene	1654
Alt Symbol	CAP-Rf, DBX, DDX14, DDX3, HLP2
Species	Human
Gene Type	protein-coding
Description	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
Other Description	ATP-dependent RNA helicase DDX3X|DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked|DEAD box protein 3, X-chromosomal|DEAD box, X isoform|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3|DEAD/H box-3|helicase-like protein 2
Swissprots	O15536 O00571 B4E3E8 A8K538
Accessions	EAW59402 EAW59403 EAW59404 EAW59405 O00571 AA481139 AB208983 BAD92220 AB451220 BAG70034 AB451343 BAG70157 AF000982 AAC51829 AF000983 AAC51830 AF061337 AAC34298 AF086430 AI698207 AK127902 AK291153 BAF83842 AK296906 BAG59462 AK297159 BAG59657 AK304661 BAG65436 AK304689 BAG65460 AK310891 AU144400 AY776161 AAV52794 BC007668 BC011819 AAH11819 BC055083 BF980241 BM454841 BM833870 BQ921695 CB107740 DA232063 DB065845 L37696 U50553 AAB95637 XM_011543892 XP_011542194 NM_001193416 NP_001180345 NM_001193417 NP_001180346 NM_001356 NP_001347 NR_126093 NR_126094 NM_024005
Function	Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'- single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation. Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5'UTRs; these functions seem to require RNA helicase activit
Subcellular Location	Nucleus speckle. Cytoplasm. Mitochondrion outer membrane. Note=Located predominantly in nuclear speckles and, at low levels, throughout the cytoplasm. Located to the outer side of nuclear pore complexes (NPC). Shuttles between the nucleus and the cytoplasm in a XPO1 and may be also in a NFX1-dependent manner. Associated with polyadenylated mRNAs in the cytoplasm and the nucleus. Predominantly located in nucleus during G(0) phase and in the cytoplasm during G1/S phase.
Top Pathways	RIG-I-like receptor signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DDX3 full length protein - ab152330 from Abcam Category Protein Source Wheat germ Species Human

Human DDX3 peptide - ab39753 from Abcam Category Peptide Species Human

Human DDX3 protein fragment - ab114616 from Abcam Category Protein Source Wheat germ Species Human

DDX3 / DDX3X Antibody Blocking Peptide - LS-E3637 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX3 / DDX3X Antibody Blocking Peptide - LS-E30218 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DDX3 / DDX3X Antibody Blocking Peptide - LS-E30219 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DDX3 / DDX3X Antibody Blocking Peptide - LS-E13009 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DDX3 Protein - H00001654-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human DDX3 Protein - H00001654-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DDX3 Peptide - NBP1-76687PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

DDX3 Blocking Peptide - NBP1-76686PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

DDX3 Peptide - P0471 from Novus Biologicals Category Peptide Species Human

DDX3-Antibody-C-term-Blocking-Peptide - BP1483b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DDX3X Blocking Peptide - 33R-6443 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DDX3X - H00001654-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

DDX3X - H00001654-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DDX3X - H00001654-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DDX3X Control Peptide - AP30282CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

DDX3X Control Peptide - AP30283CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

DDX3 Peptide - 3757P from ProSci Category Peptide Species Human

DDX3 Peptide - 3759P from ProSci Category Peptide Species Human

DDX3 fusion protein - Ag1614 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human DDX3, GST-tagged - DDX3-11901H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human DDX3X - DDX3X-28325TH from Creative Biomart Category Protein Source Wheat germ

DDX3 (L318) Peptide - BS1629P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

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