PTCH1

Gene Symbol	PTCH1
Entrez Gene	5727
Alt Symbol	BCNS, HPE7, NBCCS, PTC, PTC1, PTCH, PTCH11
Species	Human
Gene Type	protein-coding
Description	patched 1
Other Description	PTCH protein +12b|PTCH protein +4'|PTCH protein -10|PTCH protein -3,4,5|protein patched homolog 1
Swissprots	Q5VZC2 Q5R1U9 Q5R1U7 Q13463 A3KBI9 Q13635 E9PEJ8 Q86XG7 Q5VZC0 Q5R1V0
Accessions	AAR21238 AAR21239 AAR21240 EAW92631 EAW92632 Q13635 AB189436 BAD74184 AB189437 BAD74185 AB189438 BAD74186 AB189439 BAD74187 AB189440 BAD74188 AB209495 BAD92732 AB212827 AB212828 BAF47711 AB214500 BAE45300 AB233422 BAE45302 AB233423 BAE45303 AB233424 BAE45304 AB239329 BAF47712 AI358880 AI494442 AK124593 BAC85893 AK130256 BC043542 AAH43542 BC152919 AAI52920 BF195352 BM974119 BX117041 CR744004 DB093644 U43148 AAC50496 U59464 AAC50550 XM_005252102 XP_005252159 XM_011518868 XP_011517170 XM_011518869 XP_011517171 XM_011518870 XP_011517172 XM_011518871 XP_011517173 XM_011518872 XP_011517174 XM_011518873 XP_011517175 XM_011518874 XP_011517176 NM_000264 NP_000255 NM_001083602 NP_001077071 NM_001083603 NP_001077072 NM_001083604 NP_001077073 NM_001083605 NP_001077074 NM_001083606 NP_001077075 NM_001083607 NP_001077076
Function	Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. {ECO:0000269|PubMed:21537345}.
Subcellular Location	Membrane; Multi-pass membrane protein.
Tissue Specificity	In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin.
Top Pathways	Hedgehog signaling pathway, Basal cell carcinoma, cAMP signaling pathway, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human PTCH1 / Patched 1 ELISA Kit (Cell-Based ELISA) - LS-F2225 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Protein patched homolog 1 (PTCH1), Human, ELISA Kit - CSB-EL018956HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Patched Colorimetric Cell-Based ELISA Kit - CB5536 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

patched homolog 1 (Drosophila) , ELISA Kit - MBS930861 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human PTCH1 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 25 pg/ml-1600 pg/ml.

Human Protein patched homolog 1(PTCH1) ELISA kit - CSB-EL018956HU from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Human PTCH1 ELISA Kit - E028366 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human PTCH1 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the me

anti-Patched 1 antibody - ARG64324 from Arigo Biolaboratories Category ELISA Kit

PTCH1 ELISA Kit (Human) (OKCA01461) - OKCA01461 from Aviva Systems Biology Category ELISA Kit Prices $600.00 Sizes 96 wells Sensitivity 6.25 pg/mL Range 25 - 1,600 pg/mL

Human Protein patched homolog 1 (PTCH1) ELISA Kit - AE25305HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 6.25 pg/mL Range 25-1600 pg/mL

Human PTCH1 ELISA Kit - orb406186 from Biorbyt Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

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