PTCH1
| Gene Symbol | PTCH1 |
|---|---|
| Entrez Gene | 5727 |
| Alt Symbol | BCNS, HPE7, NBCCS, PTC, PTC1, PTCH, PTCH11 |
| Species | Human |
| Gene Type | protein-coding |
| Description | patched 1 |
| Other Description | PTCH protein +12b|PTCH protein +4'|PTCH protein -10|PTCH protein -3,4,5|protein patched homolog 1 |
| Swissprots | Q5VZC2 Q5R1U9 Q5R1U7 Q13463 A3KBI9 Q13635 E9PEJ8 Q86XG7 Q5VZC0 Q5R1V0 |
| Accessions | AAR21238 AAR21239 AAR21240 EAW92631 EAW92632 Q13635 AB189436 BAD74184 AB189437 BAD74185 AB189438 BAD74186 AB189439 BAD74187 AB189440 BAD74188 AB209495 BAD92732 AB212827 AB212828 BAF47711 AB214500 BAE45300 AB233422 BAE45302 AB233423 BAE45303 AB233424 BAE45304 AB239329 BAF47712 AI358880 AI494442 AK124593 BAC85893 AK130256 BC043542 AAH43542 BC152919 AAI52920 BF195352 BM974119 BX117041 CR744004 DB093644 U43148 AAC50496 U59464 AAC50550 XM_005252102 XP_005252159 XM_011518868 XP_011517170 XM_011518869 XP_011517171 XM_011518870 XP_011517172 XM_011518871 XP_011517173 XM_011518872 XP_011517174 XM_011518873 XP_011517175 XM_011518874 XP_011517176 NM_000264 NP_000255 NM_001083602 NP_001077071 NM_001083603 NP_001077072 NM_001083604 NP_001077073 NM_001083605 NP_001077074 NM_001083606 NP_001077075 NM_001083607 NP_001077076 |
| Function | Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. {ECO:0000269|PubMed:21537345}. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin. |
| Top Pathways | Hedgehog signaling pathway, Basal cell carcinoma, cAMP signaling pathway, Proteoglycans in cancer |
patched CRISPR/Cas9 KO Plasmid (h) - sc-400457 from Santa Cruz Biotechnology
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patched HDR Plasmid (h) - sc-400457-HDR from Santa Cruz Biotechnology
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patched Double Nickase Plasmid (h) - sc-400457-NIC from Santa Cruz Biotechnology
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patched Double Nickase Plasmid (h2) - sc-400457-NIC-2 from Santa Cruz Biotechnology
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patched CRISPR Activation Plasmid (h) - sc-400457-ACT from Santa Cruz Biotechnology
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patched CRISPR Activation Plasmid (h2) - sc-400457-ACT-2 from Santa Cruz Biotechnology
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patched Lentiviral Activation Particles (h) - sc-400457-LAC from Santa Cruz Biotechnology
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patched Lentiviral Activation Particles (h2) - sc-400457-LAC-2 from Santa Cruz Biotechnology
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patched siRNA (h) - sc-36192 from Santa Cruz Biotechnology
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patched shRNA Plasmid (h) - sc-36192-SH from Santa Cruz Biotechnology
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patched shRNA (h) Lentiviral Particles - sc-36192-V from Santa Cruz Biotechnology
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Patched 1/PTCH RNAi - H00005727-R02 from Novus Biologicals
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MISSION® esiRNA - EHU155311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17654 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17654 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR14044 from Sigma-Aldrich
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PTCH1 siRNA (Human) - CRH3871 from Cohesion Biosciences
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patched CRISPR/Cas9 KO Plasmid (h2) - sc-400457-KO-2 from Santa Cruz Biotechnology
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patched HDR Plasmid (h2) - sc-400457-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PTCH1 (NM_000264.3) - SHH385820 from Creative biogene
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shRNA set against Human PTCH1(NM_000264.3) - SHR149820 from Creative biogene
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shRNA set against Human PTCH1(NM_001083602.1) - SHR149856 from Creative biogene
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shRNA set against Human PTCH1(NM_001083604.1) - SHR149874 from Creative biogene
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shRNA set against Human PTCH1(NM_001083603.1) - SHR149910 from Creative biogene
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Human PTCH1 siRNA - orb264373 from Biorbyt
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