| Gene Symbol | STRA6 |
|---|---|
| Entrez Gene | 64220 |
| Alt Symbol | MCOPCB8, MCOPS9, PP14296 |
| Species | Human |
| Gene Type | protein-coding |
| Description | stimulated by retinoic acid 6 |
| Other Description | retinol binding protein 4 receptor|stimulated by retinoic acid 6 homolog|stimulated by retinoic acid gene 6 homolog|stimulated by retinoic acid gene 6 protein homolog |
| Swissprots | Q7Z3U9 Q9H9U8 Q8TB21 B7Z5M9 F5GYI8 Q9BX78 Q71RB9 Q9BX79 I3L1G8 Q6PJF8 Q7L9G1 B7Z862 D3DW54 A8K7F1 |
| Accessions | EAW99353 EAW99354 EAW99355 EAW99356 Q9BX79 AF352728 AAK30289 AF352729 AAK30290 AF370419 AAQ15255 AK022603 BAB14122 AK056125 BAG51630 AK091152 BAG52293 AK092227 BAG52498 AK291966 BAF84655 AK298921 BAH12903 AK298928 BAH12904 AK299191 BAH12965 AK302932 BAH13848 AK309676 AK310878 AY358748 AAQ89108 AY359089 AAQ89447 BC015881 AAH15881 BC025256 AAH25256 BX537413 CAD97655 CB131492 DA700543 DA746408 XM_011521883 XP_011520185 XM_011521884 XP_011520186 XM_011521885 XP_011520187 XR_931877 NM_001142617 NP_001136089 NM_001142618 NP_001136090 NM_001142619 NP_001136091 NM_001142620 NP_001136092 NM_001199040 NP_001185969 NM_001199041 NP_001185970 NM_001199042 NP_001185971 NM_022369 NP_071764 |
| Function | May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and trabecular meshwork but not in choroid and iris. {ECO:0000269|PubMed:17273977}. |
Stra6 CRISPR/Cas9 KO Plasmid (h) - sc-405364 from Santa Cruz Biotechnology
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Stra6 HDR Plasmid (h) - sc-405364-HDR from Santa Cruz Biotechnology
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Stra6 Double Nickase Plasmid (h) - sc-405364-NIC from Santa Cruz Biotechnology
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Stra6 Double Nickase Plasmid (h2) - sc-405364-NIC-2 from Santa Cruz Biotechnology
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Stra6 CRISPR Activation Plasmid (h) - sc-405364-ACT from Santa Cruz Biotechnology
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Stra6 CRISPR Activation Plasmid (h2) - sc-405364-ACT-2 from Santa Cruz Biotechnology
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Stra6 Lentiviral Activation Particles (h) - sc-405364-LAC from Santa Cruz Biotechnology
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Stra6 Lentiviral Activation Particles (h2) - sc-405364-LAC-2 from Santa Cruz Biotechnology
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Stra6 siRNA (h) - sc-89991 from Santa Cruz Biotechnology
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Stra6 shRNA Plasmid (h) - sc-89991-SH from Santa Cruz Biotechnology
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Stra6 shRNA (h) Lentiviral Particles - sc-89991-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU092561 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20762 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20762 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12208 from Sigma-Aldrich
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STRA6 siRNA (Human) - CRJ1964 from Cohesion Biosciences
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STRA6 - MBS8227275 from MyBioSource
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shRNA set against Human STRA6 (NM_022369.3) - SHH420084 from Creative biogene
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Human STRA6 siRNA - orb272465 from Biorbyt
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STRA6 shRNA Plasmid (Human) - CHJ1964 from Cohesion Biosciences
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STRA6 miRNA 3'UTR clone - MiUTR3H-11440 from Creative biogene
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STRA6 miRNA 3'UTR clone - MiUTR3H-11441 from Creative biogene
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STRA6 miRNA 3'UTR clone - MiUTR3H-11442 from Creative biogene
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STRA6 miRNA 3'UTR clone - MiUTR3H-11443 from Creative biogene
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STRA6 miRNA 3'UTR clone - MiUTR3H-11444 from Creative biogene
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