RBM4

Gene Symbol RBM4
Entrez Gene 5936
Alt Symbol LARK, RBM4A, ZCCHC21, ZCRB3A
Species Human
Gene Type protein-coding
Description RNA binding motif protein 4
Other Description RNA-binding motif protein 4a|RNA-binding protein 4|lark homolog|transcriptional coactivator CoAZ|zinc finger CCHC-type and RNA binding motif 3A
Swissprots Q8WU85 B4E1U0 B3KUN0 O02916 E7EQS3 Q4VC48 Q6P1P2 Q9BWF3
Accessions EAW74555 EAW74556 Q9BWF3 AF087999 AK094046 AK097592 BAG53492 AK225071 AK303984 BAG64902 AL832566 CAH10593 AW575232 BC000307 AAH00307 BC021120 AAH21120 BC032735 AAH32735 BC064960 AAH64960 CB242056 DA046115 DC366746 EU447002 ABZ92531 HG503892 HG503893 U89505 AAC51293 NM_001198843 NP_001185772 NM_001198844 NP_001185773 NM_002896 NP_002887
Function RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome
Subcellular Location Nucleus. Nucleus, nucleolus. Nucleus speckle. Cytoplasm. Cytoplasmic granule. Note=Undergoes continuous nucleocytoplasmic shuttling. Upon nuclear import colocalizes with SR proteins in nuclear speckles. Arsenite stress-induced phosphorylation increases its subcellular relocalization from the nucleus to the cytoplasm and to cytoplasmic stress granules (SG) via a p38 MAPK signaling pathway. Primarily localized in nucleus and nucleoli under cell growth conditions and accumulated in the cytoplasm and cytoplasm perinuclear granules upon muscle cell differentiation.
Tissue Specificity Expressed in the cerebellum. Expressed in neurons and glial cells, including layers II neurons in the frontal cortex and CA1 pyramidal neurons in the hippocampus. Expressed in heart, liver, pancreas, skeletal muscle, placenta, primary fibroblasts and peripheral blood monocytes (at protein level). Ubiquitously expressed. Highly expressed in heart, placenta and skeletal muscle. Weakly expressed in pancreas, kidney, liver, lung and brain. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:18708123}.

RBM4 (E-3) - sc-373852 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RBM4 (E-3): sc-373852. Western blot analysis of RBM4 expression in non-transfected (A) and human RBM4 transfected (B) whole cell lysates.

RBM4 (E-17) - sc-82352 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RBM4 (E-17): sc-82352. Western blot analysis of RBM4 expression in non-transfected: sc-117752 (A) and human RBM4 transfected: sc-369849 (B) 293T whole cell lysates.

RBM4 (H-100) - sc-98346 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RBM4 (H-100): sc-98346. Western blot analysis of RBM4 expression in Jurkat whole cell lysate.

RBM4 (I-14) - sc-82354 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RBM4 (I-14): sc-82354. Western blot analysis of RBM4 expression in HeLa nuclear extract.

Anti-RBM4 antibody - ab154760 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-RBM4 antibody (ab154760) at 1/5000 dilution + HeLa whole cell lysate at 30 µg

Anti-RBM4 antibody - ab130624 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-RBM4 antibody (ab130624) at 1/100 dilution + MDA-MB453 cell line lysates at 35 µg

Anti-RBM4 antibody - ab96658 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-RBM4 antibody (ab96658) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-RBM4 / LARK Antibody (aa152-201) - LS-C80329 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MCF7 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.

Anti-RBM4 / LARK Antibody (aa177-207) - LS-C80328 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MCF7 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.

Anti-RBM4 / LARK Antibody (aa334-362) - LS-C162499 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
RBM4 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The RBM4 antibody detected the RBM4 protein (arrow).

Anti-RBM4 / LARK Antibody - LS-C333032 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using RBM4 antibody.

Anti-RBM4 / LARK Antibody (aa304-316) - LS-C185796 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
RBM4 antibody detects RBM4 protein at nucleus by immunofluorescent analysis. A431 cells were fixed in 4% paraformaldehyde at RT for 15 min. RBM4 protein stained by RBM4 antibody diluted at 1:500.

Anti-RBM4 / LARK Antibody (C-Terminus) - LS-C55375 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-RBM4 / LARK Antibody (aa334-362, AP) - LS-C217151 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBM4 / LARK Antibody (aa334-362, APC) - LS-C217152 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBM4 / LARK Antibody (aa334-362, Biotin) - LS-C217153 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBM4 / LARK Antibody (aa334-362, FITC) - LS-C217154 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBM4 / LARK Antibody (aa334-362, Azide-free, HRP) - LS-C217155 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBM4 / LARK Antibody (aa334-362, PE) - LS-C217156 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBM4 / LARK Antibody (aa333-362) - LS-C324568 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

RBM4 Antibody - NBP2-20106 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RBM4 Antibody [NBP2-20106] - Sample (30 ug of whole cell lysate) A: Neuro2A B: GL261 C: C8D30 10% SDS PAGE gel, diluted at 1:5000.

Anti-RBM4 (AB1) antibody produced in rabbit - AV40425 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: MCF7 (<B>Cat. No. AV40425</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 0.5 μg/mL in cell type MCF7

Anti-RBM4 (AB2) antibody produced in rabbit - AV40426 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: MCF7 (<B>Cat. No. AV40426</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 0.5 μg/mL in cell type MCF7

Anti-RBM4 antibody produced in rabbit - SAB2700917 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RBM4: <B>Cat. No. SAB2700917</B>: Western Blot analysis of RBM4 in extracts from <B>Lanes</B><BR/>A. HepG2 using <B>Cat. No. SAB2700917</B> at a 1:1000 dilution.

Anti-RBM4 antibody produced in rabbit - SAB2701529 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RBM4: <B>Cat. No. SAB2701529</B>: Western Blot analysis of RBM4 in extracts from <B>Lanes</B><BR/>A. HeLa using <B>Cat. No. SAB2701529</B> at a 1:5000 dilution.
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