| Gene Symbol |
RBM4
|
| Entrez Gene |
5936
|
| Alt Symbol |
LARK, RBM4A, ZCCHC21, ZCRB3A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RNA binding motif protein 4
|
| Other Description |
RNA-binding motif protein 4a|RNA-binding protein 4|lark homolog|transcriptional coactivator CoAZ|zinc finger CCHC-type and RNA binding motif 3A
|
| Swissprots |
Q8WU85 B4E1U0 B3KUN0 O02916 E7EQS3 Q4VC48 Q6P1P2 Q9BWF3
|
| Accessions |
EAW74555 EAW74556 Q9BWF3 AF087999 AK094046 AK097592 BAG53492 AK225071 AK303984 BAG64902 AL832566 CAH10593 AW575232 BC000307 AAH00307 BC021120 AAH21120 BC032735 AAH32735 BC064960 AAH64960 CB242056 DA046115 DC366746 EU447002 ABZ92531 HG503892 HG503893 U89505 AAC51293 NM_001198843 NP_001185772 NM_001198844 NP_001185773 NM_002896 NP_002887
|
| Function |
RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus. Nucleus speckle. Cytoplasm. Cytoplasmic granule. Note=Undergoes continuous nucleocytoplasmic shuttling. Upon nuclear import colocalizes with SR proteins in nuclear speckles. Arsenite stress-induced phosphorylation increases its subcellular relocalization from the nucleus to the cytoplasm and to cytoplasmic stress granules (SG) via a p38 MAPK signaling pathway. Primarily localized in nucleus and nucleoli under cell growth conditions and accumulated in the cytoplasm and cytoplasm perinuclear granules upon muscle cell differentiation.
|
| Tissue Specificity |
Expressed in the cerebellum. Expressed in neurons and glial cells, including layers II neurons in the frontal cortex and CA1 pyramidal neurons in the hippocampus. Expressed in heart, liver, pancreas, skeletal muscle, placenta, primary fibroblasts and peripheral blood monocytes (at protein level). Ubiquitously expressed. Highly expressed in heart, placenta and skeletal muscle. Weakly expressed in pancreas, kidney, liver, lung and brain. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:18708123}.
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