Gene Symbol |
ITGAV
|
Entrez Gene |
3685
|
Alt Symbol |
CD51, MSK8, VNRA, VTNR
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
integrin, alpha V
|
Other Description |
antigen identified by monoclonal antibody L230|integrin alpha-V|integrin alphaVbeta3|integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)|vitronectin receptor subunit alpha
|
Swissprots |
B0LPF4 P06756 A0AV67 Q59EB7 D3DPG8 B7Z883 B7ZLX0 Q53SK4 E7EWZ6 Q6LD15
|
Accessions |
AAA20462 AAA61631 AAG03000 AAY24257 ABY87533 AGC09592 EAX10933 EAX10934 P06756 AB209894 BAD93131 AK302550 BAG63819 AK302990 BAH13869 AK309711 BC047454 BC072686 BC126231 AAI26232 BC136442 AAI36443 BC144100 AAI44101 BQ101180 BQ129340 CB962576 CN409399 DA736912 EF560727 ABQ59037 M14648 AAA36808 N83286 XM_006712513 XP_006712576 NM_001144999 NP_001138471 NM_001145000 NP_001138472 NM_002210 NP_002201
|
Function |
The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
|
Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
Top Pathways |
Proteoglycans in cancer, PI3K-Akt signaling pathway, Phagosome, Focal adhesion, Dilated cardiomyopathy
|