SCYL2
| Gene Symbol | SCYL2 |
|---|---|
| Entrez Gene | 55681 |
| Alt Symbol | CVAK104 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SCY1-like 2 (S. cerevisiae) |
| Other Description | SCY1-like protein 2|coated vesicle-associated kinase of 104 kDa |
| Swissprots | Q6P3W7 Q9P2I7 Q9NVH3 Q9H7V5 Q96ST4 A8KAB5 Q96EF4 |
| Accessions | EAW97630 EAW97631 EAW97632 EAW97633 EAW97634 EAW97635 EAW97636 Q6P3W7 AB037781 BAA92598 AK000936 BAA91433 AK001597 BAA91778 AK024274 BAB14869 AK026160 AK027551 BAB55194 AK125091 AK292980 BAF85669 AL133044 BC011525 BC012387 AAH12387 BC063798 AAH63798 XM_005269018 XP_005269075 XM_011538559 XP_011536861 XM_011538560 XP_011536862 XM_011538561 XP_011536863 NM_017988 NP_060458 |
| Function | Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L- lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system. {ECO:0000269|PubMed:15809293, ECO:0000269|PubMed:16914521}. |
| Subcellular Location | Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Note=According to PubMed:15809293, plasma membrane-associated in clathrin-coated vesicles. According to PubMed:16914521, colocalizes to the trans- Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes. |
SCYL2 CRISPR/Cas9 KO Plasmid (h) - sc-405141 from Santa Cruz Biotechnology
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SCYL2 HDR Plasmid (h) - sc-405141-HDR from Santa Cruz Biotechnology
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SCYL2 Double Nickase Plasmid (h) - sc-405141-NIC from Santa Cruz Biotechnology
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SCYL2 Double Nickase Plasmid (h2) - sc-405141-NIC-2 from Santa Cruz Biotechnology
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SCYL2 CRISPR Activation Plasmid (h) - sc-405141-ACT from Santa Cruz Biotechnology
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SCYL2 CRISPR Activation Plasmid (h2) - sc-405141-ACT-2 from Santa Cruz Biotechnology
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SCYL2 Lentiviral Activation Particles (h) - sc-405141-LAC from Santa Cruz Biotechnology
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SCYL2 Lentiviral Activation Particles (h2) - sc-405141-LAC-2 from Santa Cruz Biotechnology
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SCYL2 siRNA (h) - sc-95795 from Santa Cruz Biotechnology
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SCYL2 shRNA Plasmid (h) - sc-95795-SH from Santa Cruz Biotechnology
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SCYL2 shRNA (h) Lentiviral Particles - sc-95795-V from Santa Cruz Biotechnology
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SCYL2 RNAi - H00055681-R02 from Novus Biologicals
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MISSION® esiRNA - EHU114881 from Sigma-Aldrich
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MISSION® siRNA - SIHK2051 from Sigma-Aldrich
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MISSION® siRNA - SIHK2049 from Sigma-Aldrich
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MISSION® siRNA - SIHK2050 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18981 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12430 from Sigma-Aldrich
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SCYL2 siRNA (Human) - CRJ0829 from Cohesion Biosciences
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SCYL2 - MBS8215043 from MyBioSource
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shRNA set against Human SCYL2 (NM_017988.4) - SHH403204 from Creative biogene
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shRNA set against Human SCYL2(NM_017988.4) - SHR210522 from Creative biogene
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Human SCYL2 siRNA - orb271330 from Biorbyt
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SCYL2 shRNA Plasmid (Human) - CHJ0829 from Cohesion Biosciences
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