Gene Symbol | Pla2g4a |
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Entrez Gene | 24653 |
Alt Symbol | Pla2c, Pla2g4, cPLA2 |
Species | Rat |
Gene Type | protein-coding |
Description | phospholipase A2, group IVA (cytosolic, calcium-dependent) |
Other Description | cytosolic phospholipase A2|phospholipase A2 cytosolic|phospholipase A2 group IVA |
Swissprots | P50393 |
Accessions | EDM09590 P50393 BC070940 AAH70940 S77829 AAB33847 U38376 AAC21591 NM_133551 NP_598235 |
Function | Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. |
Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Translocates to membrane vesicles in a calcium-dependent fashion. {ECO:0000250}. |
Tissue Specificity | In brain tissue, expressed in low levels in olfactory mitral and granule cells, in hippocampal pyramidal cells and in dentate and cerebellar granule cells. |
Top Pathways | Choline metabolism in cancer, Ovarian steroidogenesis, Inflammatory mediator regulation of TRP channels, Oxytocin signaling pathway, Glutamatergic synapse |
Recombinant Rat Cytosolic phospholipase A2(Pla2g4a) - CSB-YP018097RA CSB-EP018097RA CSB-BP018097RA CSB-MP018097RA from Cusabio
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Cytosolic phospholipase A2 (Pla2g4a), Recombinant Protein - MBS1000161 from MyBioSource
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