| Gene Symbol |
IGHMBP2
|
| Entrez Gene |
3508
|
| Alt Symbol |
CATF1, CMT2S, HCSA, HMN6, SMARD1, SMUBP2, ZFAND7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
immunoglobulin mu binding protein 2
|
| Other Description |
ATP-dependent helicase IGHMBP2|DNA-binding protein SMUBP-2|GF-1|cardiac transcription factor 1|glial factor 1|immunoglobulin mu-binding protein 2|zinc finger, AN1-type domain 7
|
| Swissprots |
A0PJD2 P38935 Q14177 Q00443
|
| Accessions |
AAA70430 EAW74729 P38935 AB208802 BAD92039 AF052128 AK091539 AK123166 AK312565 BAG35460 BC000290 AAH00290 BC015666 BC025299 AAH25299 BC041808 BC052278 BC062312 BC080519 BC105088 AAI05089 BC105090 AAI05091 BE302389 DB448398 L14754 AAA53082 M64979 AAA58611 XM_005273974 XP_005274031 XM_005273975 XP_005274032 XM_005273976 XP_005274033 XM_011544994 XP_011543296 XR_247198 XR_949903 NM_002180 NP_002171
|
| Function |
5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver- type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation (By similarity). DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV. {ECO:0000250, ECO:0000269|PubMed:19158098, ECO:0000269|PubMed:19299493}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19299493}. Cytoplasm {ECO:0000269|PubMed:19299493}. Cell projection, axon {ECO:0000250}. Note=Colocalizes with the translation initiation factor EIF4G2. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in all tissues examined.
|