| Gene Symbol | Tnfrsf1a |
|---|---|
| Entrez Gene | 21937 |
| Alt Symbol | CD120a, FPF, TNF-R, TNF-R-I, TNF-R1, TNF-R55, TNF-alphaR1, TNFAR, TNFR60, TNFRI, TNFRp55, TNFalpha-R1, Tnfr-2, Tnfr1, p55, p55-R |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | tumor necrosis factor receptor superfamily, member 1a |
| Other Description | TNF receptor alpha chain|TNF-RI|TNF-alpha-R1|TNFR-I|p60|tumor necrosis factor receptor 1|tumor necrosis factor receptor superfamily member 1A|tumor necrosis factor receptor type I |
| Swissprots | P25118 |
| Accessions | AAA40465 EDK99828 P25118 AK154388 BAE32554 AK159989 BAE35539 AK178992 AK181159 AK181531 AK190321 AK206708 AK206824 AK207044 AK211886 AY541589 AAS48428 AY541590 AAS48429 BC004599 AAH04599 BC052675 AAH52675 BC096429 AAH96429 CK624043 L26349 AAA59361 M59377 AAA40464 M60468 AAA39751 X57796 CAA40936 X59238 CAA41922 NM_011609 NP_035739 |
| Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Top Pathways | Sphingolipid signaling pathway, Herpes simplex infection, TNF signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Tuberculosis |