| Gene Symbol |
PALLD
|
| Entrez Gene |
23022
|
| Alt Symbol |
CGI-151, CGI151, MYN, PNCA1, SIH002
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
palladin, cytoskeletal associated protein
|
| Other Description |
myoneurin|palladin|sarcoma antigen NY-SAR-77
|
| Swissprots |
Q7Z3W0 B7ZMM5 B5MD56 Q8WX93 Q86WE8 Q9Y2J6 Q9UQF5 Q7L3E0 B3KTG2 Q9Y3E9 Q8N1M2 Q9UGA0
|
| Accessions |
AAY40987 CCO13786 EAX04799 Q8WX93 AB023209 BAA76836 AF077041 AAD27774 AF151909 AAD34146 AF464873 AAL69964 AI418424 AK000845 AK025843 AK095512 BAG53074 AK096458 BAC04796 AL050093 CAB43265 AW248292 AY211921 AAO65174 BC013867 AAH13867 BC140850 AAI40851 BC144666 AAI44667 BX537391 CAD97633 DA048169 DA211938 DB257974 XM_005262861 XP_005262918 XM_005262866 XP_005262923 XM_011531768 XP_011530070 XM_011531769 XP_011530071 XM_011531770 XP_011530072 XM_011531771 XP_011530073 XM_011531772 XP_011530074 XM_011531773 XP_011530075 XM_011531774 XP_011530076 XM_011531775 XP_011530077 XM_011531776 XP_011530078 NM_001166108 NP_001159580 NM_001166109 NP_001159581 NM_001166110 NP_001159582 NM_016081 NP_057165
|
| Function |
Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to stress fibers and Z lines.
|
| Tissue Specificity |
Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is overexpressed in FA6, HPAF, IMIM-PC2, SUIT-2 and PancTu-II sporadic pancreatic cancer cell lines. {ECO:0000269|PubMed:11598191}.
|
