PLEKHB1
| Gene Symbol | PLEKHB1 |
|---|---|
| Entrez Gene | 58473 |
| Alt Symbol | KPL1, PHR1, PHRET1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | pleckstrin homology domain containing, family B (evectins) member 1 |
| Other Description | PH domain containing protein in retina 1|PH domain containing, retinal 1|PH domain-containing family B member 1|PH domain-containing protein in retina 1|evectin-1|pleckstrin homology domain retinal protein 1|pleckstrin homology domain-containing family B member 1 |
| Swissprots | A8K0Q5 B7Z716 Q9UI44 B2RBP1 Q9UI37 Q9UBF5 Q9UF11 |
| Accessions | AAG13807 EAW74900 EAW74901 EAW74902 EAW74903 EAW74904 EAW74905 EAW74906 Q9UF11 AB209716 BAD92953 AF081583 AAF21786 AF093249 AAF16684 AF100612 AAF18932 AF101054 AAF18572 AK054725 BAG51417 AK289620 BAF82309 AK289909 BAF82598 AK290109 BAF82798 AK296033 BAH12242 AK301299 BAH13452 AK311158 AK314748 BAG37288 AL712105 BC008075 AAH08075 CK819503 DC305763 EB387039 JF432611 ADZ15828 U89715 AAF16675 XM_011545192 XP_011543494 XM_011545193 XP_011543495 XM_011545194 XP_011543496 NM_001130033 NP_001123505 NM_001130034 NP_001123506 NM_001130035 NP_001123507 NM_001130036 NP_001123508 NM_021200 NP_067023 |
| Function | Required for proper localization of retinogeniculate projections but not for eye-specific segregation. {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:10585447}. Cytoplasm {ECO:0000250}. Note=Localizes to the apical juxta- nuclear Golgi region of the cytoplasm (By similarity). Membrane- associated. Highly expressed in the outer segments of photoreceptor cells, both in rods and cones. {ECO:0000250}. |
| Tissue Specificity | Highly expressed in retina and brain. Levels are very low or not detectable in all other tissues tested. {ECO:0000269|PubMed:10585447}. |
PHR1 CRISPR/Cas9 KO Plasmid (h) - sc-412905 from Santa Cruz Biotechnology
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PHR1 HDR Plasmid (h) - sc-412905-HDR from Santa Cruz Biotechnology
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PHR1 Double Nickase Plasmid (h) - sc-412905-NIC from Santa Cruz Biotechnology
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PHR1 Double Nickase Plasmid (h2) - sc-412905-NIC-2 from Santa Cruz Biotechnology
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PHR1 CRISPR Activation Plasmid (h) - sc-412905-ACT from Santa Cruz Biotechnology
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PHR1 CRISPR Activation Plasmid (h2) - sc-412905-ACT-2 from Santa Cruz Biotechnology
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PHR1 Lentiviral Activation Particles (h) - sc-412905-LAC from Santa Cruz Biotechnology
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PHR1 Lentiviral Activation Particles (h2) - sc-412905-LAC-2 from Santa Cruz Biotechnology
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PHR1 siRNA (h) - sc-61336 from Santa Cruz Biotechnology
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PHR1 shRNA Plasmid (h) - sc-61336-SH from Santa Cruz Biotechnology
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PHR1 shRNA (h) Lentiviral Particles - sc-61336-V from Santa Cruz Biotechnology
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PLEKHB1/PHR1 RNAi - H00058473-R01 from Novus Biologicals
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MISSION® esiRNA - EHU059321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16955 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16955 from Sigma-Aldrich
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PLEKHB1 siRNA (Human) - CRJ1708 from Cohesion Biosciences
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shRNA set against Human PLEKHB1 (NM_021200.2) - SHH377548 from Creative biogene
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PLEKHB1 shRNA Plasmid (Human) - CHJ1708 from Cohesion Biosciences
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PLEKHB1 miRNA 3'UTR clone - MiUTR3H-09364 from Creative biogene
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PLEKHB1 miRNA 3'UTR clone - MiUTR3H-09365 from Creative biogene
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PLEKHB1 miRNA 3'UTR clone - MiUTR3H-09366 from Creative biogene
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PLEKHB1 miRNA 3'UTR clone - MiUTR3H-09367 from Creative biogene
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PLEKHB1 miRNA 3'UTR clone - MiUTR3H-09368 from Creative biogene
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