| Gene Symbol |
RNF182
|
| Entrez Gene |
221687
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 182
|
| Other Description |
E3 ubiquitin-protein ligase RNF182
|
| Swissprots |
Q8NBG3 B2RDG2 Q8N6D2
|
| Accessions |
EAW55349 EAW55350 Q8N6D2 AK090576 BAC03481 AK098091 AK315528 BAG37909 AW731636 BC030666 AAH30666 BC050030 AAH50030 DA123125 DA803766 DB094450 DB176198 DQ892438 ABM83364 DQ892444 ABM83370 DQ895648 ABM86574 DQ895649 ABM86575 NM_001165032 NP_001158504 NM_001165033 NP_001158505 NM_001165034 NP_001158506 NM_152737 NP_689950
|
| Function |
E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. {ECO:0000269|PubMed:18298843}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:18298843}.
|
| Tissue Specificity |
Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains. {ECO:0000269|PubMed:18298843}.
|
![Western Blot: RNF182 Overexpression Lysate (Adult Normal) [NBL1-15438] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RNF182.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8974_RNF182%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15438-img0002.jpg)