CLTC
| Gene Symbol | CLTC |
|---|---|
| Entrez Gene | 1213 |
| Alt Symbol | CHC, CHC17, CLH-17, CLTCL2, Hc |
| Species | Human |
| Gene Type | protein-coding |
| Description | clathrin, heavy chain (Hc) |
| Other Description | clathrin heavy chain 1|clathrin heavy chain on chromosome 17|clathrin, heavy polypeptide (Hc)|clathrin, heavy polypeptide-like 2 |
| Swissprots | Q86TF2 Q6N0A0 D3DU00 Q00610 |
| Accessions | EAW94395 EAW94396 EAW94397 EAW94398 EAW94399 Q00610 AB073891 AK127134 BC015854 BC036430 AAH36430 BC051800 AAH51800 BC054489 AAH54489 BX473803 BX640615 CAE45761 D21260 BAA04801 DA248028 X55878 CAA39363 XM_005257012 XP_005257069 XM_011524279 XP_011522581 XM_011524280 XP_011522582 XM_011524281 XP_011522583 NM_001288653 NP_001275582 NM_004859 NP_004850 |
| Function | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. |
| Subcellular Location | Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Membrane, coated pit {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Top Pathways | Huntington's disease, Endocytosis, Lysosome, Bacterial invasion of epithelial cells, Endocrine and other factor-regulated calcium reabsorption |
Clathrin HC CRISPR/Cas9 KO Plasmid (h) - sc-400863 from Santa Cruz Biotechnology
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Clathrin HC HDR Plasmid (h) - sc-400863-HDR from Santa Cruz Biotechnology
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Clathrin HC Double Nickase Plasmid (h) - sc-400863-NIC from Santa Cruz Biotechnology
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Clathrin HC Double Nickase Plasmid (h2) - sc-400863-NIC-2 from Santa Cruz Biotechnology
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Clathrin HC CRISPR Activation Plasmid (h) - sc-400863-ACT from Santa Cruz Biotechnology
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Clathrin HC CRISPR Activation Plasmid (h2) - sc-400863-ACT-2 from Santa Cruz Biotechnology
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Clathrin HC Lentiviral Activation Particles (h) - sc-400863-LAC from Santa Cruz Biotechnology
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Clathrin HC Lentiviral Activation Particles (h2) - sc-400863-LAC-2 from Santa Cruz Biotechnology
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Clathrin HC siRNA (h) - sc-35067 from Santa Cruz Biotechnology
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Clathrin HC shRNA Plasmid (h) - sc-35067-SH from Santa Cruz Biotechnology
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Clathrin HC shRNA (h) Lentiviral Particles - sc-35067-V from Santa Cruz Biotechnology
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Clathrin Heavy Chain 1/CHC17 RNAi - H00001213-R01 from Novus Biologicals
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MISSION® esiRNA - EHU039481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6271 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6271 from Sigma-Aldrich
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CLTC siRNA (Human) - CRH0865 from Cohesion Biosciences
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CLTC - MBS8236766 from MyBioSource
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Clathrin HC CRISPR/Cas9 KO Plasmid (h2) - sc-400863-KO-2 from Santa Cruz Biotechnology
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Clathrin HC HDR Plasmid (h2) - sc-400863-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CLTC (NM_004859.3) - SHH265757 from Creative biogene
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shRNA set against Human CLTC(NM_004859.3) - SHG184855 from Creative biogene
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Human CLTC siRNA - orb261367 from Biorbyt
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CLTC shRNA Plasmid (Human) - CHH0865 from Cohesion Biosciences
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CLTC miRNA 3'UTR clone - MiUTR1H-02242 from Creative biogene
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