| Gene Symbol |
ATRN
|
| Entrez Gene |
8455
|
| Alt Symbol |
DPPT-L, MGCA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
attractin
|
| Other Description |
attractin-2|mahogany homolog|mahogany protein
|
| Swissprots |
Q9NZ58 Q9UDF5 Q5VYW3 O95414 Q9NZ57 O75882 Q5TDA4 Q9UC75 Q9NTQ3 Q3MIT3 Q9NTQ4 Q9NU01 A8KAE5 O60295 Q5TDA2
|
| Accessions |
AAF72881 AAF72882 EAX10530 EAX10531 EAX10532 O75882 AA771958 AB011120 BAA25474 AF106861 AAD03057 AK000356 AK293010 BAF85699 AK302730 BAG63948 BC009724 AAH09724 BC101705 AAI01706 BE326239 DA368237 DB240822 EC440053 XM_005260860 XP_005260917 XM_011529389 XP_011527691 NM_001207047 NP_001193976 NM_139321 NP_647537 NM_139322 NP_647538 NM_012070
|
| Function |
Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Isoform 3: Secreted.
|
| Tissue Specificity |
Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes. {ECO:0000269|PubMed:10811918, ECO:0000269|PubMed:17261078}.
|