Gene Symbol | ATRN |
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Entrez Gene | 8455 |
Alt Symbol | DPPT-L, MGCA |
Species | Human |
Gene Type | protein-coding |
Description | attractin |
Other Description | attractin-2|mahogany homolog|mahogany protein |
Swissprots | Q9NZ58 Q9UDF5 Q5VYW3 O95414 Q9NZ57 O75882 Q5TDA4 Q9UC75 Q9NTQ3 Q3MIT3 Q9NTQ4 Q9NU01 A8KAE5 O60295 Q5TDA2 |
Accessions | AAF72881 AAF72882 EAX10530 EAX10531 EAX10532 O75882 AA771958 AB011120 BAA25474 AF106861 AAD03057 AK000356 AK293010 BAF85699 AK302730 BAG63948 BC009724 AAH09724 BC101705 AAI01706 BE326239 DA368237 DB240822 EC440053 XM_005260860 XP_005260917 XM_011529389 XP_011527691 NM_001207047 NP_001193976 NM_139321 NP_647537 NM_139322 NP_647538 NM_012070 |
Function | Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). {ECO:0000250}. |
Subcellular Location | Isoform 3: Secreted. |
Tissue Specificity | Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes. {ECO:0000269|PubMed:10811918, ECO:0000269|PubMed:17261078}. |
Attractin CRISPR/Cas9 KO Plasmid (h) - sc-406420 from Santa Cruz Biotechnology
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Attractin HDR Plasmid (h) - sc-406420-HDR from Santa Cruz Biotechnology
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Attractin Double Nickase Plasmid (h) - sc-406420-NIC from Santa Cruz Biotechnology
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Attractin Double Nickase Plasmid (h2) - sc-406420-NIC-2 from Santa Cruz Biotechnology
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Attractin CRISPR Activation Plasmid (h) - sc-406420-ACT from Santa Cruz Biotechnology
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Attractin CRISPR Activation Plasmid (h2) - sc-406420-ACT-2 from Santa Cruz Biotechnology
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Attractin Lentiviral Activation Particles (h) - sc-406420-LAC from Santa Cruz Biotechnology
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Attractin Lentiviral Activation Particles (h2) - sc-406420-LAC-2 from Santa Cruz Biotechnology
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Attractin siRNA (h) - sc-77343 from Santa Cruz Biotechnology
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Attractin shRNA Plasmid (h) - sc-77343-SH from Santa Cruz Biotechnology
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Attractin shRNA (h) Lentiviral Particles - sc-77343-V from Santa Cruz Biotechnology
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Attractin RNAi - H00008455-R04 from Novus Biologicals
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Attractin RNAi - H00008455-R05 from Novus Biologicals
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MISSION® esiRNA - EHU066681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3754 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3754 from Sigma-Aldrich
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ATRN siRNA (Human) - CRH5543 from Cohesion Biosciences
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Attractin RNAi - H00008455-R06 from Novus Biologicals
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ATRN - MBS828437 from MyBioSource
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shRNA set against Human ATRN (NM_139321.2) - SHH243486 from Creative biogene
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Human ATRN siRNA - orb266045 from Biorbyt
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ATRN shRNA Plasmid (Human) - CHH5543 from Cohesion Biosciences
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ATRN miRNA 3'UTR clone - MiUTR3H-05690 from Creative biogene
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ATRN miRNA 3'UTR clone - MiUTR4H-TG10654 from Creative biogene
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