| Gene Symbol |
ESCO2
|
| Entrez Gene |
157570
|
| Alt Symbol |
2410004I17Rik, EFO2, RBS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
establishment of sister chromatid cohesion N-acetyltransferase 2
|
| Other Description |
ECO1 homolog 2|N-acetyltransferase ESCO2
|
| Swissprots |
Q56NI9 B3KW59 Q49AP4
|
| Accessions |
EAW63538 Q56NI9 AF306675 AF306676 AF306677 AF306678 AF306679 AK124215 BAG54021 AL832666 AY882862 AAX68677 BC017933 BC034641 AAH34641 BC040615 BC141418 AAI41419 BC146562 AAI46563 XM_011544421 XP_011542723 XM_011544422 XP_011542724 XR_949378 XR_949379 NM_001017420 NP_001017420
|
| Function |
Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3. {ECO:0000269|PubMed:15821733, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19907496}. Chromosome {ECO:0000269|PubMed:19907496}.
|
| Tissue Specificity |
Widely expressed in fetal tissues. In adult, it is expressed in thymus, placenta and small intestine. {ECO:0000269|PubMed:15821733}.
|