Gene Symbol | AATF |
---|---|
Entrez Gene | 26574 |
Alt Symbol | BFR2, CHE-1, CHE1, DED |
Species | Human |
Gene Type | protein-coding |
Description | apoptosis antagonizing transcription factor |
Other Description | apoptosis-antagonizing transcription factor|protein AATF|rb-binding protein Che-1 |
Swissprots | Q9P0A4 A6NCJ6 B3KQ26 Q9NY61 Q9UNX5 |
Accessions | EAW57575 Q9NY61 AF083208 AAD52016 AF161395 AAF28955 AJ249940 CAB57451 AK026173 AK057229 BAG51888 AK130740 BC000591 AAH00591 DQ892097 ABM83023 DQ895290 ABM86216 XM_011524611 XP_011522913 XM_011546799 XP_011545101 XR_934439 XR_951958 NM_012138 NP_036270 |
Function | May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272}. |
Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. |
Tissue Specificity | Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus. {ECO:0000269|PubMed:10783144, ECO:0000269|PubMed:11027528}. |
Rabbit anti-AATF/Che-1 Antibody, Affinity Purified - PLA0162 from Sigma-Aldrich
|
||||||||||
Apoptosis Antagonizing Transcription Factor, AATF, Human, ELISA Kit - E-EL-H0477 from ARP American Research Products
|
||||||||||
Apoptosis Antagonizing Transcription Factor, Human, ELISA Kit - E01A0531 from ARP American Research Products
|
||||||||||
Apoptosis Antagonizing Transcription Factor, AATF, Mouse, ELISA Kit - E-EL-M0139 from ARP American Research Products
|
||||||||||
Apoptosis Antagonizing Transcription Factor, AATF, Rabbit, ELISA Kit - E-EL-RB0793 from ARP American Research Products
|
||||||||||
Apoptosis Antagonizing Transcription Factor, AATF, Chicken, ELISA Kit - E-EL-Ch0311 from ARP American Research Products
|
||||||||||
Apoptosis Antagonizing Transcription Factor, AATF, Porcine, ELISA Kit - E-EL-P1367 from ARP American Research Products
|
||||||||||
Apoptosis Antagonizing Transcription Factor, AATF, Sheep, ELISA Kit - E-EL-S0401 from ARP American Research Products
|
||||||||||
Apoptosis Antagonizing Transcription Factor, AATF, Monkey, ELISA Kit - E-EL-MK1853 from ARP American Research Products
|
||||||||||
Human AATF ELISA Kit - HA0538 from NeoScientific
|
||||||||||
Anserine AATF ELISA Kit - AA0538 from NeoScientific
|
||||||||||
Human AATF(Apoptosis Antagonizing Transcription Factor) ELISA Kit - E-EL-H0477 from Elabscience
|
||||||||||
Apoptosis Antagonizing Transcription Factor, ELISA Kit - MBS749072 from MyBioSource
|
||||||||||
Apoptosis Antagonizing Transcription Factor, ELISA Kit - MBS748564 from MyBioSource
|
||||||||||
Apoptosis Antagonizing Transcription Factor, ELISA Kit - MBS751651 from MyBioSource
|
||||||||||
Apoptosis Antagonizing Transcription Factor, ELISA Kit - MBS754986 from MyBioSource
|
||||||||||
Apoptosis Antagonizing Transcription Factor, ELISA Kit - MBS752745 from MyBioSource
|
||||||||||
apoptosis antagonizing transcription factor, ELISA Kit - MBS9341642 from MyBioSource
|
||||||||||
Apoptosis Antagonizing Transcription Factor, ELISA Kit - MBS755153 from MyBioSource
|
||||||||||
Apoptosis Antagonizing Transcription Factor, ELISA Kit - MBS750551 from MyBioSource
|
||||||||||
Human AATF(Apoptosis Antagonizing Transcription Factor) ELISA Kit - E-EL-H0477 from Iwai North America Inc.
|
||||||||||
Human Apoptosis Antagonizing Transcription Factor ELISA Kit - abx253443 from Abbexa
|
||||||||||
Human AATF ELISA Kit (Sandwich ELISA) - LS-F20929 from LifeSpan Bioscience
|
||||||||||
Human AATF ELISA Kit - E000151 from Biobool
|
||||||||||
Human AATF ELISA Kit - EHA0538 from ABclonal
|