AATF

Gene Symbol AATF
Entrez Gene 26574
Alt Symbol BFR2, CHE-1, CHE1, DED
Species Human
Gene Type protein-coding
Description apoptosis antagonizing transcription factor
Other Description apoptosis-antagonizing transcription factor|protein AATF|rb-binding protein Che-1
Swissprots Q9P0A4 A6NCJ6 B3KQ26 Q9NY61 Q9UNX5
Accessions EAW57575 Q9NY61 AF083208 AAD52016 AF161395 AAF28955 AJ249940 CAB57451 AK026173 AK057229 BAG51888 AK130740 BC000591 AAH00591 DQ892097 ABM83023 DQ895290 ABM86216 XM_011524611 XP_011522913 XM_011546799 XP_011545101 XR_934439 XR_951958 NM_012138 NP_036270
Function May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272}.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Tissue Specificity Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus. {ECO:0000269|PubMed:10783144, ECO:0000269|PubMed:11027528}.

Che-1 (C-19) - sc-70032 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Che-1 (K-16) - sc-70033 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Che-1 (H-115) - sc-292611 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Che-1 (AATF2B6) - sc-81225 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Che-1 (AATF2B6): sc-81225 Western Blot analysis of human recombinant Che-1 fusion protein.

Che-1 (Y-25) - sc-133455 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Che-1 (Y-25): sc-133455. Western blot analysis of Che-1 expression in Hep G2 whole cell lysate.

Anti-AATF antibody - ab39631 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-AATF antibody (ab39631) at 0.5 µg/mlLane 2 : Anti-AATF antibody (ab39631) at 1 µg/mlLane 3 : Anti-AATF antibody (ab39631) at 2 µg/mlLane 1 : Human small intestine cell lysate Lane 2 : Human small intestine cell lysate Lane 3 : Human small intestine cell lysate Lysates/proteins at 15 µg per lane.Secondaryanti-rabbit IgG HRP at 1/10000 dilution

Anti-AATF antibody - ab65248 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AATF antibody (ab65248) at 1/500 dilutionLane 1 : HeLa cell extractLane 2 : HepG2 cell extractLane 3 : COLO205 cell extractLane 4 : HUVEC cell extractLane 5 : HUVEC cell extract with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-AATF antibody - ab72148 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AATF antibody (ab72148) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µg

Anti-AATF antibody [AATF2B6] - ab50826 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone AATF2B6

Anti-AATF Antibody (clone 3C7) IHC-plus™ - LS-B11447 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3C7
Anti-AATF antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11447 concentration 10 ug/ml.

Anti-AATF Antibody (aa151-250, Azide-free) - LS-C126872 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-AATF Antibody (aa171-220) - LS-C29956 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
AATF antibody LS-C29956 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-AATF Antibody (clone AATF2B6) - LS-C184271 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone AATF2B6

Anti-AATF Antibody (FITC) - LS-C211569 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AATF Antibody (Biotin) - LS-C211570 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AATF Antibody (HRP) - LS-C211568 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AATF Antibody - LS-C211567 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AATF Antibody (FITC) - LS-C211572 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AATF Antibody (HRP) - LS-C211573 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AATF Antibody (aa10-59) - LS-C119287 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa cells/HepG2 cells/COLO205 cells/HUVEC cells, using AATF Antibody. The lane on the right is treated with the synthesized peptide.

Anti-AATF Antibody (Biotin) - LS-C211574 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AATF Antibody (aa125-175) - LS-C287862 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AATF Antibody (C-Terminus) - LS-C287864 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AATF Antibody (aa237-523, Biotin) - LS-C299486 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AATF Antibody (aa237-523, FITC) - LS-C302980 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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