SUV39H2
| Gene Symbol | SUV39H2 |
|---|---|
| Entrez Gene | 79723 |
| Alt Symbol | KMT1B |
| Species | Human |
| Gene Type | protein-coding |
| Description | suppressor of variegation 3-9 homolog 2 (Drosophila) |
| Other Description | H3-K9-HMTase 2|histone H3-K9 methyltransferase 2|histone-lysine N-methyltransferase SUV39H2|lysine N-methyltransferase 1B|su(var)3-9 homolog 2 |
| Swissprots | D3DRT4 Q5JSS4 Q8ND06 Q6I9Y3 Q5JSS5 Q9H5I1 |
| Accessions | EAW86253 EAW86254 EAW86255 EAW86256 EAW86257 Q9H5I1 AK027067 BAB15645 AK222565 AK225369 AL834488 CAD39146 BC007754 AAH07754 BC029360 AAH29360 BU928392 CR457372 CAG33653 DB040298 DQ896015 ABM87014 EU176399 ABW03850 XM_006717503 XP_006717566 XM_011519661 XP_011517963 XM_011519662 XP_011517964 NM_001193424 NP_001180353 NM_001193425 NP_001180354 NM_001193426 NP_001180355 NM_001193427 NP_001180356 NM_024670 NP_078946 NR_034181 |
| Function | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chrom |
| Subcellular Location | Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=Associates with centromeric constitutive heterochromatin. {ECO:0000250}. |
| Top Pathways | Lysine degradation |
SUV39H2 (N-15) - sc-54342 from Santa Cruz Biotechnology
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SUV39H2 (E-14) - sc-54340 from Santa Cruz Biotechnology
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SUV39H2 (Z-23) - sc-130886 from Santa Cruz Biotechnology
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Anti-KMT1B / SUV39H2 antibody - C-terminal - ab71683 from Abcam
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Anti-KMT1B / SUV39H2 antibody - N-terminal - ab135125 from Abcam
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Anti-SUV39H2 Antibody (C-Terminus) - LS-C55542 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (aa367-395, APC) - LS-C270763 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (aa367-395, AP) - LS-C270764 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (aa367-395, Biotin) - LS-C270765 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (aa367-395, FITC) - LS-C270766 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (aa367-395, Azide-free, HRP) - LS-C270767 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (aa367-395, PE) - LS-C270768 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (C-Terminus, AP) - LS-C283259 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (C-Terminus, Biotin) - LS-C283260 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (C-Terminus, APC) - LS-C283261 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (C-Terminus, FITC) - LS-C283262 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (N-Terminus, APC) - LS-C283263 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (aa101-150) - LS-C200737 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (C-Terminus, Azide-free, HRP) - LS-C283264 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (C-Terminus, PE) - LS-C283265 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (N-Terminus, AP) - LS-C283266 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (N-Terminus, Biotin) - LS-C283267 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (N-Terminus, FITC) - LS-C283268 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (N-Terminus, Azide-free, HRP) - LS-C283269 from LifeSpan Bioscience
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Anti-SUV39H2 Antibody (His150) - LS-C177259 from LifeSpan Bioscience
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