SUV39H2

Gene Symbol	SUV39H2
Entrez Gene	79723
Alt Symbol	KMT1B
Species	Human
Gene Type	protein-coding
Description	suppressor of variegation 3-9 homolog 2 (Drosophila)
Other Description	H3-K9-HMTase 2|histone H3-K9 methyltransferase 2|histone-lysine N-methyltransferase SUV39H2|lysine N-methyltransferase 1B|su(var)3-9 homolog 2
Swissprots	D3DRT4 Q5JSS4 Q8ND06 Q6I9Y3 Q5JSS5 Q9H5I1
Accessions	EAW86253 EAW86254 EAW86255 EAW86256 EAW86257 Q9H5I1 AK027067 BAB15645 AK222565 AK225369 AL834488 CAD39146 BC007754 AAH07754 BC029360 AAH29360 BU928392 CR457372 CAG33653 DB040298 DQ896015 ABM87014 EU176399 ABW03850 XM_006717503 XP_006717566 XM_011519661 XP_011517963 XM_011519662 XP_011517964 NM_001193424 NP_001180353 NM_001193425 NP_001180354 NM_001193426 NP_001180355 NM_001193427 NP_001180356 NM_024670 NP_078946 NR_034181
Function	Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chrom
Subcellular Location	Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=Associates with centromeric constitutive heterochromatin. {ECO:0000250}.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human KMT1B / SUV39H2 protein fragment - ab80288 from Abcam Category Protein Prices $239.00 Sizes 25 µg Source E. coli Species Human

Human KMT1B / SUV39H2 peptide - ab23082 from Abcam Category Peptide Species Human

SUV39H2 Antibody Blocking Peptide - LS-E1965 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SUV39H2 Antibody Blocking Peptide - LS-E1966 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SUV39H2 Antibody Blocking Peptide - LS-E25461 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SUV39H2 Antibody Blocking Peptide - LS-E6389 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SUV39H2 Protein - H00079723-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

SUV39H2 Peptide - P0330 from Novus Biologicals Category Peptide Species Human

SUV39H2 Peptide - P0329 from Novus Biologicals Category Peptide Species Human

SUV39H2-Antibody-C-term-Blocking-Peptide - BP1281b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SUV39H2-Antibody-N-term-Blocking-Peptide - BP1281a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SUV39H2-Antibody-C-term-Blocking-Peptide - BP19115b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SUV39H2 blocking peptide - GTX25264-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

SUV39H2 Blocking Peptide - 33R-4870 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SUV39H2 Blocking Peptide - abx063978 from Abbexa Category Peptide Species Human, Monkey, Pig

KMT1B / SUV39H2 Peptide - AC21-0290-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SUV39H2 / KMT1B - H00079723-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

SUV39H2 Peptide - 46-451P from ProSci Category Peptide

SUV39H2 fusion protein - Ag1882 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant SUV39H2 protein - 31359 from ActiveMotif Category Protein Prices $395.00 Sizes 50 µg Source E. coli Species Human

Recombinant Human SUV39H2, GST-tagged - SUV39H2-472H from Creative Biomart Category Protein Source E.Coli .

Recombinant Human SUV39H2 - SUV39H2-29907TH from Creative Biomart Category Protein Source E. coli

Recombinant Human SUV39H2, GST-tagged - SUV39H2-3063H from Creative Biomart Category Protein Source E.coli Species Human

SUV39H2 Blocking Peptide - CBP2784 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey, Pig

KMT1B (H150) Peptide - BS2900P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

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