Gene Symbol | TRAF5 |
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Entrez Gene | 7188 |
Alt Symbol | MGC:39780, RNF84 |
Species | Human |
Gene Type | protein-coding |
Description | TNF receptor-associated factor 5 |
Other Description | RING finger protein 84 |
Swissprots | Q6FHY1 B4E0A2 B4DIS9 O00463 |
Accessions | EAW93419 EAW93420 EAW93421 EAW93422 O00463 AB000509 BAA25262 AK126502 BAG54338 AK295766 BAG58591 AK303286 BAG64364 BC029600 AAH29600 BC032830 BM453281 BU676629 CD709275 CR536557 CAG38794 DB218840 DB290838 GQ129370 ACT64504 GQ129371 ACT64505 U69108 AAC51329 XM_011509956 XP_011508258 XM_011509957 XP_011508259 XM_011509958 XP_011508260 XM_011509959 XP_011508261 XM_011509960 XP_011508262 NM_001033910 NP_001029082 NM_004619 NP_004610 NM_145759 NP_665702 |
Function | Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. {ECO:0000269|PubMed:15121867}. |
Subcellular Location | Cytoplasm {ECO:0000305|PubMed:15121867}. Cytoplasm, cytosol {ECO:0000269|PubMed:15121867}. |
Tissue Specificity | Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood. |
Top Pathways | Small cell lung cancer, Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection, TNF signaling pathway |
TRAF5 (B-6) - sc-271145 from Santa Cruz Biotechnology
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TRAF5 (C-19) - sc-6195 from Santa Cruz Biotechnology
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TRAF5 (C-4) - sc-133252 from Santa Cruz Biotechnology
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TRAF5 (E-4) - sc-74502 from Santa Cruz Biotechnology
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TRAF5 (E-8) - sc-271144 from Santa Cruz Biotechnology
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TRAF5 (E-5) - sc-74503 from Santa Cruz Biotechnology
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TRAF5 (H-257) - sc-7220 from Santa Cruz Biotechnology
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Anti-TRAF5 antibody - ab200122 from Abcam
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Anti-TRAF5 antibody - ab47539 from Abcam
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Anti-TRAF5 antibody [55A219] - ab115589 from Abcam
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Anti-TRAF5 antibody [55A219] - ab12123 from Abcam
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Anti-TRAF5 Antibody (aa1-20) - LS-C10906 from LifeSpan Bioscience
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Anti-TRAF5 Antibody (aa77-186) - LS-C10915 from LifeSpan Bioscience
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Anti-TRAF5 Antibody (aa77-186) - LS-C90670 from LifeSpan Bioscience
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Anti-TRAF5 Antibody (aa181-437, Biotin) - LS-C297606 from LifeSpan Bioscience
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Anti-TRAF5 Antibody (aa181-437, FITC) - LS-C302933 from LifeSpan Bioscience
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Anti-TRAF5 Antibody - LS-C342250 from LifeSpan Bioscience
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Anti-TRAF5 Antibody (aa181-437) - LS-C296684 from LifeSpan Bioscience
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Anti-TRAF5 Antibody (aa1-20) - LS-C148302 from LifeSpan Bioscience
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Anti-TRAF5 Antibody (aa62-75) - LS-C313261 from LifeSpan Bioscience
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Anti-TRAF5 Antibody (aa77-186, clone 55A219) IHC-plus⢠- LS-B2088 from LifeSpan Bioscience
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TRAF-5 Antibody - NB100-56178 from Novus Biologicals
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TRAF-5 Antibody (55A219) - NB600-1107 from Novus Biologicals
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TRAF-5 Antibody - AF3280 from Novus Biologicals
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TRAF-5 Antibody - NBP1-31856 from Novus Biologicals
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