Gene Symbol | PDHA2 |
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Entrez Gene | 5161 |
Alt Symbol | PDHAL |
Species | Human |
Gene Type | protein-coding |
Description | pyruvate dehydrogenase (lipoamide) alpha 2 |
Other Description | PDHE1-A type II|pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial|pyruvate dehydrogenase, E1-alpha polypeptide, testis specific |
Swissprots | Q6NXQ1 P29803 Q4VC02 Q0VDI5 B2R9Q3 |
Accessions | AAA60232 AAF14652 CBH19409 CBH30590 EAX06063 P29803 AK313872 BAG36600 BC030697 AAH30697 BC066953 AAH66953 BC094760 AAH94760 BC119656 AAI19657 BC119657 AAI19658 BC127637 AAI27638 BC127638 AAI27639 NM_005390 NP_005381 |
Function | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:16436377}. |
Subcellular Location | Mitochondrion matrix. |
Tissue Specificity | Testis. Expressed in postmeiotic spermatogenic cells. {ECO:0000269|PubMed:22750801}. |
Top Pathways | Glycolysis / Gluconeogenesis, Citrate cycle (TCA cycle), Central carbon metabolism in cancer, Glucagon signaling pathway, Pyruvate metabolism |
PDHA2 CRISPR/Cas9 KO Plasmid (h) - sc-410927 from Santa Cruz Biotechnology
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PDHA2 HDR Plasmid (h) - sc-410927-HDR from Santa Cruz Biotechnology
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PDHA2 Double Nickase Plasmid (h) - sc-410927-NIC from Santa Cruz Biotechnology
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PDHA2 Double Nickase Plasmid (h2) - sc-410927-NIC-2 from Santa Cruz Biotechnology
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PDHA2 CRISPR Activation Plasmid (h) - sc-410927-ACT from Santa Cruz Biotechnology
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PDHA2 CRISPR Activation Plasmid (h2) - sc-410927-ACT-2 from Santa Cruz Biotechnology
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PDHA2 Lentiviral Activation Particles (h) - sc-410927-LAC from Santa Cruz Biotechnology
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PDHA2 Lentiviral Activation Particles (h2) - sc-410927-LAC-2 from Santa Cruz Biotechnology
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PDHA2 siRNA (h) - sc-89026 from Santa Cruz Biotechnology
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PDHA2 shRNA Plasmid (h) - sc-89026-SH from Santa Cruz Biotechnology
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PDHA2 shRNA (h) Lentiviral Particles - sc-89026-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU119121 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16556 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16556 from Sigma-Aldrich
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PDHA2 siRNA (Human) - CRH3441 from Cohesion Biosciences
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shRNA set against Human PDHA2(NM_005390.4) - SHR101698 from Creative biogene
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Human PDHA2 siRNA - orb263943 from Biorbyt
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PDHA2 shRNA Plasmid (Human) - CHH3441 from Cohesion Biosciences
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PDHA2 miRNA 3'UTR clone - MiUTR1H-07737 from Creative biogene
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