| Gene Symbol |
MAP4K3
|
| Entrez Gene |
8491
|
| Alt Symbol |
GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase kinase kinase 3
|
| Other Description |
MAPK/ERK kinase kinase kinase 3|MEK kinase kinase 3|germinal center kinase-like kinase|germinal center kinase-related protein kinase
|
| Swissprots |
Q9Y6R5 Q9UDM5 Q8IVH8 Q8IVH7 Q6IQ39
|
| Accessions |
AAF19240 AAN75849 AAN75850 AAY14734 EAX00346 EAX00347 Q8IVH8 AK021553 BAG51037 AK291467 BAF84156 AK299889 BAG61735 AK314487 AK316144 BAH14515 BC060880 BC071579 AAH71579 DA409370 EU832785 ACE87796 GQ129258 ACT64392 XR_939730 NM_001270425 NP_001257354 NM_003618 NP_003609
|
| Function |
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9275185}.
|
| Tissue Specificity |
Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver. {ECO:0000269|PubMed:9275185}.
|
| Top Pathways |
MAPK signaling pathway
|
![Western Blot: MAP4K3 Overexpression Lysate (Adult Normal) [NBL1-12860] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MAP4K3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10570_MAP4K3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12860-img0002.jpg)